Finger Tapping Task Activation vs. TMS Hotspot: Different Locations and Networks
Finger Tapping Task Activation vs. TMS Hotspot: Different Locations and Networks
复制标题
手指敲击任务激活与 TMS 热点：不同的位置和网络
DOI：
10.1007/s10548-019-00741-9
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发表时间：
2019-11
期刊：
影响因子：
2.7
通讯作者：
Zhang Jian
中科院分区：
文献类型：
--
作者：
Wang Jue;Meng Hai-Jiang;Ji Gong-Jun;Jing Ying;Wang Hong-Xiao;Deng Xin-Ping;Feng Zi-Jian;Zhao Na;Zang Yu-Feng;Zhang Jian
功能磁共振成像（fMRI）和经颅磁刺激（TMS）已被用于非侵入性定位人体运动功能区。这些部位在临床上可作为经颅磁刺激治疗的刺激靶点。然而，已有报道指出，手指敲击的fMRI激活与TMS热点并没有很好地重叠。本研究的目的是测量手指敲击fMRI激活与TMS热点之间的距离，更重要的是通过静息状态fMRI比较网络差异。30名健康参与者分别进行静息态功能磁共振成像、任务功能磁共振成像和经颅磁刺激热点定位。我们发现手指敲击fMRI激活与TMS热点的位置存在显著差异。具体来说，手指敲击的fMRI激活比TMS在运动前区的热点更侧向。以fMRI激活峰和TMS热点作为静息状态功能连通性分析的种子。与TMS热点相比，手指轻敲fMRI激活峰与双侧运动前区、脑岛、壳核、右侧苍白球等功能连接更为紧密。研究结果表明，手指敲击激活网络比经颅磁刺激热点更密集，表明针对fMRI激活区域的经颅磁刺激治疗可能产生更远的效果，对经颅磁刺激治疗运动障碍更有帮助。
Both functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS) have been used to non-invasively localize the human motor functional area. These locations can be clinically used as stimulation target of TMS treatment. However, it has been reported that the finger tapping fMRI activation and TMS hotspot were not well-overlapped. The aim of the current study was to measure the distance between the finger tapping fMRI activation and the TMS hotspot, and more importantly, to compare the network difference by using resting-state fMRI. Thirty healthy participants underwent resting-state fMRI, task fMRI, and then TMS hotspot localization. We found significant difference of locations between finger tapping fMRI activation and TMS hotspot. Specifically, the finger tapping fMRI activation was more lateral than the TMS hotspot in the premotor area. The fMRI activation peak and TMS hotspot were taken as seeds for resting-state functional connectivity analyses. Compared with TMS hotspot, finger tapping fMRI activation peak showed more intensive functional connectivity with, e.g., the bilateral premotor, insula, putamen, and right globus pallidus. The findings more intensive networks of finger tapping activation than TMS hotspot suggest that TMS treatment targeting on the fMRI activation area might result in more remote effects and would be more helpful for TMS treatment on movement disorders.
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DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
2.7
作者：
Kallioniemi, Elisa;Julkunen, Petro
通讯作者：
Julkunen, Petro
使用功能性磁共振成像成像的神经元活性中的自发波动在脑肿瘤患者中的术前感官图：初始体验。
影响因子：
4.8
作者：
Zhang D;Johnston JM;Fox MD;Leuthardt EC;Grubb RL;Chicoine MR;Smyth MD;Snyder AZ;Raichle ME;Shimony JS
通讯作者：
Shimony JS
影响因子：
4.6
作者：
通讯作者：
--
DOI：
10.1073/pnas.0502762102
发表时间：
2005-08-30
影响因子：
11.1
作者：
Lehéricy, S;Benali, H;Doyon, J
通讯作者：
Doyon, J