Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
Amplification of progenitors in the mammalian telencephalon includes a new radial glial cell type.
复制标题
DOI：
10.1038/ncomms3125
复制
发表时间：
2013
影响因子：
16.6
通讯作者：
Goetz, Magdalena
中科院分区：
文献类型：
--
作者：
Pilz, Gregor-Alexander;Shitamukai, Atsunori;Reillo, Isabel;Pacary, Emilie;Schwausch, Julia;Stahl, Ronny;Ninkovic, Jovica;Snippert, Hugo J.;Clevers, Hans;Godinho, Leanne;Guillemot, Francois;Borrell, Victor;Matsuzaki, Fumio;Goetz, Magdalena
对于特定脑区神经元数量扩张的机制，我们仍然知之甚少。不同物种中神经元数量的增加通常是由室管膜下区中祖细胞分裂数量的增加来预测的。在这里，我们提出了放射状胶质细胞及其后代在腹侧端脑，该地区最大的脑室下区在小鼠脑神经发生的实时成像分析。我们观察到一种新类型的祖细胞，包括双极放射状胶质细胞分裂在亚顶端的位置，并产生进一步的增殖后代的谱系扩增。这种新型的祖细胞的频率增加，不仅在较大的克隆小鼠外侧神经节隆起，但也在大脑皮层的回旋物种，并在诱导小鼠大脑皮层的回旋。这意味着这种新型的放射状胶质细胞在个体发育和胚胎发育中的关键作用。 神经前体细胞的扩增介导脑区域的扩展。利用小鼠腹侧前脑祖细胞扩增的成像，作者鉴定了一种高频率的新祖细胞类型，他们也表明这种类型存在于其他物种的扩展脑区。
The mechanisms governing the expansion of neuron number in specific brain regions are still poorly understood. Enlarged neuron numbers in different species are often anticipated by increased numbers of progenitors dividing in the subventricular zone. Here we present live imaging analysis of radial glial cells and their progeny in the ventral telencephalon, the region with the largest subventricular zone in the murine brain during neurogenesis. We observe lineage amplification by a new type of progenitor, including bipolar radial glial cells dividing at subapical positions and generating further proliferating progeny. The frequency of this new type of progenitor is increased not only in larger clones of the mouse lateral ganglionic eminence but also in cerebral cortices of gyrated species, and upon inducing gyrification in the murine cerebral cortex. This implies key roles of this new type of radial glia in ontogeny and phylogeny. Amplification of neural progenitor cells mediates expansion of brain regions. Using imaging of progenitor cell amplification in the mouse ventral forebrain, the authors identify a new progenitor type with high frequency, which they also show to be present in expanded brain regions of other species.
登录
查看更多内容
DOI：
10.1093/cercor/bhr301
发表时间：
2012-02
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Kelava I;Reillo I;Murayama AY;Kalinka AT;Stenzel D;Tomancak P;Matsuzaki F;Lebrand C;Sasaki E;Schwamborn JC;Okano H;Huttner WB;Borrell V
通讯作者：
Borrell V
DOI：
10.1073/pnas.0308600100
发表时间：
2004-03-02
影响因子：
11.1
作者：
Haubensak, W;Attardo, A;Huttner, WB
通讯作者：
Huttner, WB
影响因子：
3.7
作者：
Reillo, Isabel;Borrell, Victor
通讯作者：
Borrell, Victor
影响因子：
13.9
作者：
Kriegstein A;Alvarez-Buylla A
通讯作者：
Alvarez-Buylla A
影响因子：
3.7
作者：
Garcia-Moreno, Fernando;Vasistha, Navneet A.;Molnar, Zoltan
通讯作者：
Molnar, Zoltan