Effect of conjugated linoleic acid on blood pressure: a meta-analysis of randomized, double-blind placebo-controlled trials.
Effect of conjugated linoleic acid on blood pressure: a meta-analysis of randomized, double-blind placebo-controlled trials.
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共轭亚油酸对血压的影响：随机、双盲安慰剂对照试验的荟萃分析
DOI：
10.1186/s12944-015-0010-9
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发表时间：
2015-02-18
影响因子：
4.5
通讯作者：
Qin LQ
中科院分区：
文献类型：
--
作者：
Yang J;Wang HP;Zhou LM;Zhou L;Chen T;Qin LQ
背景大量动物实验证明共轭亚油酸（CLA）具有降低大鼠血压的作用。然而，这种有益的效果是不完全支持的研究human.MethodsWe检索Pubmed，科克伦图书馆，和ClinicalTrials.gov数据库相关的随机，双盲安慰剂对照试验到2014年8月进行荟萃分析。一个随机效应模型被用来计算联合治疗effects.ResultsEight研究与9项试验，其中涉及638名参与者补充CLA范围从2.0克/天至6.8克/天，被列入本荟萃分析。与安慰剂相比，收缩压和舒张压的合并变化估计值分别为-0.03 mmHg（95% CI：-2.29，2.24，P = 0.98）和0.69 mmHg（95% CI：-1.41，2.80，P = 0.52）。收缩压研究间无显著异质性;然而，舒张压存在显著异质性。出版偏见没有发现收缩压和舒张压BPs.ConclusionThe结果的荟萃分析不支持的总体有利的效果，CLA补充BP调节。
BackgroundNumerous studies on animals evidenced that conjugated linoleic acid (CLA) could decrease blood pressure (BP) in several rat models. However, such beneficial effect is not completely supported by studies on humans.MethodsWe searched the Pubmed, Cochrane Library, and the ClinicalTrials.gov databases for relevant randomized, double-blind placebo-controlled trials up to August 2014 to perform a meta-analysis. A random-effects model was used to calculate the combined treatment effects.ResultsEight studies with nine trials, which involved 638 participants with CLA supplementation ranging from 2.0 g/day to 6.8 g/day, were included in this meta-analysis. Compared with placebo, the pooled estimate of change was −0.03 mm Hg (95% CI: −2.29, 2.24, P = 0.98) and 0.69 mm Hg (95% CI: −1.41, 2.80, P = 0.52) in systolic and diastolic BPs, respectively. No significant heterogeneity across studies for systolic BP; however, substantial heterogeneity for diastolic BP was identified. Publication bias was not found for both systolic and diastolic BPs.ConclusionThe findings of this meta-analysis did not support the overall favorable effect of CLA supplementation on BP regulation.
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影响因子：
2.7
作者：
Engberink, M. F.;Geleijnse, J. M.;Brouwer, I. A.
通讯作者：
Brouwer, I. A.
影响因子：
3.6
作者：
Laso, Nuria;Brugue, Emma;Lafuente, Amalia
通讯作者：
Lafuente, Amalia
影响因子：
2.9
作者：
Aryaeian N;Shahram F;Djalali M;Eshragian MR;Djazayeri A;Sarrafnejad A;Naderi N;Chamari M;Fatehi F;Zarei M
通讯作者：
Zarei M
DOI：
10.1016/j.bbrc.2004.08.139
发表时间：
2004-10-15
影响因子：
3.1
作者：
Inoue, N;Nagao, K;Yanagita, T
通讯作者：
Yanagita, T
影响因子：
4.2
作者：
Ritzenthaler, KL;McGuire, MK;McGuire, MA
通讯作者：
McGuire, MA