Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors.
Fgf10 regulates transition period of cortical stem cell differentiation to radial glia controlling generation of neurons and basal progenitors.
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DOI：
10.1016/j.neuron.2009.06.006
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发表时间：
2009-07-16
期刊：
影响因子：
16.2
通讯作者：
O'Leary, Dennis D. M.
中科院分区：
文献类型：
--
作者：
Sahara, Setsuko;O'Leary, Dennis D. M.
放射状胶质细胞（RG）是皮质神经元和基底祖细胞（BP）的祖细胞，由具有干细胞特性的神经上皮细胞（NC）分化而来。我们发现，形态，FGF10，是瞬时表达的NC与NC分化为RG的过渡期相一致。Fgf10的靶向缺失延迟RG分化，而过表达具有相反的作用。延迟RG分化Fgf10突变体中发生选择性地在吻侧皮质，延长对称NC分裂增加祖细胞数量，加上延迟和最初减少的神经元和BP的生产。RG最终分化为数量过多的神经元和BPs，导致额区切向扩张和层厚度增加。因此，瞬时Fgf10表达调节RG的及时分化，并通过该功能，决定早期祖细胞扩增期的长度和神经发生的开始，并最终决定特定皮质区域的祖细胞和神经元的数量。
Radial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differentiate from neuroepithelial cells (NCs) with stem cell properties. We show that the morphogen, Fgf10, is transiently expressed by NCs coincident with the transition period of NC differentiation into RG. Targeted deletion of Fgf10 delays RG differentiation, whereas overexpression has opposing effects. Delayed RG differentiation in Fgf10 mutants occurs selectively in rostral cortex, paralleled by an extended period of symmetric NC divisions increasing progenitor number, coupled with delayed and initially diminished production of neurons and BPs. RG eventually differentiate in excess number and overproduce neurons and BPs rostrally resulting in tangential expansion of frontal areas and increased laminar thickness. Thus, transient Fgf10 expression regulates timely differentiation of RG, and through this function, determines both length of the early progenitor expansion phase and onset of neurogenesis, and ultimately the number of progenitors and neurons fated to specific cortical areas.
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