Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung.
Introduction and utility of liquid-based cytology on aspiration biopsy of peripheral nodular lesions of the lung.
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DOI：
10.3892/ol.2013.1763
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发表时间：
2014-03
期刊：
影响因子：
2.9
通讯作者：
Tsuneyama K
中科院分区：
文献类型：
--
作者：
Imura J;Abe K;Uchida Y;Shibata M;Tsunematsu K;Sathoh M;Miwa S;Nakajima T;Nomoto K;Hayashi S;Tsuneyama K
在本研究中，抽吸活检细胞学（ABC）被用于诊断周围结节性病变在肺（PNLL），液基细胞学（LBC）进行了收集的材料，以评估它与传统的方法（CM）相比。受试者包括130例接受计算机断层扫描（CT）引导下ABC治疗PNLL的病例。73例行肿瘤切除术，病理确诊，57例放射学检查肿瘤无变化，随访。来自这些患者的活检样本和来自抽吸针的灌洗液用于分析。通过离心灌洗液获得细胞材料，并根据ThinPrep方法通过两种方法制备样品，即直接涂片和LBC。将样品分为三种诊断：i）良性，ii）疑似恶性和iii）恶性。LBC在72%的病例中采集了适当的样本，但CM仅在36%的病例中采集了样本。除少数特殊病例外，两种方法的细胞图像无明显差异。LBC本身的敏感性为68%，特异性为61%，准确性为65%，而LBC和活检的组合显着提高这些数字分别为94%，81%和84%。LBC的引入有助于CT引导下ABC细胞病理学诊断PNLL。LBC能够检查富含细胞成分的适当样本，并支持基于活检的诊断。这两种方法的组合提供了更高的诊断准确性，并且LBC被认为是评估这些病理样品的极好方法。
In the present study, aspiration biopsy cytology (ABC) was used for the diagnosis of peripheral nodular lesions in the lung (PNLL), and liquid-based cytology (LBC) was carried out on the material collected to evaluate it in comparison with the conventional method (CM). The subjects comprised 130 cases that underwent computed tomography (CT)-guided ABC for PNLL. A total of 73 cases received a tumor resection, with a diagnosis based on the pathology, while 57 cases were followed up, as the tumor showed no change on the radiological examinations. Biopsy samples from these patients and lavage fluid from the aspiration needles were used for analysis. Cellular material was obtained by centrifugation of the lavage fluid, and samples were prepared by two methods, direct smearing and LBC according to the ThinPrep method. The samples were categorized into three diagnoses: i) Benign, ii) suspicion of malignancy and iii) malignant. Appropriate samples were collected in 72% of cases by LBC, but only in 36% of cases by the CM. There was no marked difference in cellular images between the two methods, with the exception of a few specific cases. LBC on its own provided sensitivity at 68%, specificity at 61% and accuracy at 65%, while a combination of LBC and biopsy markedly improved these figures to 94, 81 and 84%, respectively. The introduction of LBC is considered useful for the cytopathological diagnosis of PNLL by CT-guided ABC. LBC enables the examination of appropriate samples rich in cellular components and supports a biopsy-based diagnosis. A combination of these two methods provides even higher diagnostic accuracy, and LBC is considered an excellent method to evaluate these pathological samples.
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