Spite versus cheats: competition among social strategies shapes virulence in Pseudomonas aeruginosa.
Spite versus cheats: competition among social strategies shapes virulence in Pseudomonas aeruginosa.
复制标题
DOI：
10.1111/j.1558-5646.2012.01706.x
复制
发表时间：
2012-11
期刊：
影响因子：
--
通讯作者：
Buckling A
中科院分区：
文献类型：
--
作者：
Inglis RF;Brown SP;Buckling A
社会相互作用已被证明在细菌进化和毒力中起着重要作用。大多数的实证研究只考虑孤立的社会特征，但许多社会特征，如生产恶意细菌素（抗竞争毒素）和铁清除铁载体（一种公共产品）的机会致病菌铜绿假单胞菌，经常同时表达。至关重要的是，在相同的竞争条件下，细菌素生产和铁载体作弊都是有利的，我们开发了理论并进行了实验，以确定细菌素生产基因型的成功如何受到易感竞争对手的社会作弊的影响，以及对疾病严重程度（毒力）的影响。与我们的理论预测一致，我们发现恶意基因型在与公共利益骗子竞争时，在较高的本地频率上受到青睐。此外，当恶意基因型与作弊者竞争时，恶意频率与毒力之间的关系显著改变。这些结果证实了同时考虑多种社会特征的生态和进化重要性。此外，我们的研究结果与最近的理论相一致的入侵条件强互惠（帮助合作者和伤害非合作者）。
Social interactions have been shown to play an important role in bacterial evolution and virulence. The majority of empirical studies conducted have only considered social traits in isolation, yet numerous social traits, such as the production of spiteful bacteriocins (anticompetitor toxins) and iron-scavenging siderophores (a public good) by the opportunistic pathogen Pseudomonas aeruginosa, are frequently expressed simultaneously. Crucially, both bacteriocin production and siderophore cheating can be favored under the same competitive conditions, and we develop theory and carry out experiments to determine how the success of a bacteriocin-producing genotype is influenced by social cheating of susceptible competitors and the resultant impact on disease severity (virulence). Consistent with our theoretical predictions, we find that the spiteful genotype is favored at higher local frequencies when competing against public good cheats. Furthermore, the relationship between spite frequency and virulence is significantly altered when the spiteful genotype is competed against cheats compared with cooperators. These results confirm the ecological and evolutionary importance of considering multiple social traits simultaneously. Moreover, our results are consistent with recent theory regarding the invasion conditions for strong reciprocity (helping cooperators and harming noncooperators).
登录
查看更多内容
影响因子：
64.8
作者：
HAMILTON, WD
通讯作者：
HAMILTON, WD
影响因子：
2.1
作者：
Gardner, A.;West, S. A.
通讯作者：
West, S. A.
影响因子：
1.4
作者：
Bowles, S;Gintis, H
通讯作者：
Gintis, H
影响因子：
4.1
作者：
Brown SP;Fredrik Inglis R;Taddei F
通讯作者：
Taddei F
影响因子：
9.2
作者：
Brown, Sam P.;Le Chat, Ludovic;Taddei, Francois
通讯作者：
Taddei, Francois