The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review.

The Use of Essential Oils and Their Isolated Compounds for the Treatment of Oral Candidiasis: A Literature Review.
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DOI:
10.1155/2021/1059274
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发表时间:
2021
期刊:
Evidence-based complementary and alternative medicine : eCAM
影响因子:
--
通讯作者:
Dias de Castro R
Dias de Castro R
中科院分区:
其他
文献类型:
--
作者:
Ferreira EDS;Rosalen PL;Benso B;de Cássia Orlandi Sardi J;Denny C;Alves de Sousa S;Queiroga Sarmento Guerra F;de Oliveira Lima E;Almeida Freires I;Dias de Castro R

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在这篇文献综述中,我们介绍了有关精油(Eos)抗真菌活性的主要科学发现,该活性适用于治疗口腔念珠菌病的新药配方。系统地搜索了7个文献数据库,寻找符合条件的体外试验和临床试验。从生物活性、植物种类、植物化学成分、研究设计和方法学质量等方面对选定的文章进行筛选。共纳入26篇文献,其中21篇为体外研究,5篇为临床试验。在植物化学成分中,柠檬醛和百里香酚活性最强。临床试验表明,百里香和多花紫草提取物对口腔念珠菌病有潜在的治疗作用。有必要对这些EO进行进一步的非临床和临床研究,以确定它们用于治疗口腔念珠菌病的潜在用途和安全性。
In this literature review, we present the main scientific findings on the antifungal activity of essential oils (EOs) applicable for a new drug formulation to treat oral candidiasis. Seven literature databases were systematically searched for eligible in vitro and clinical trials. Selected articles were screened for biological activity, botanical species, phytochemical composition, study design, and methodological quality. A total of 26 articles were included in the review, of which 21 were in vitro studies and 5 clinical trials. The most promising EOs were obtained from Allium tubeorosum, Cinnamomum cassia, Cinnamomum zeylanicum, and Coriandrum sativum L. Among the phytochemicals, citral and thymol were the most active. Clinical trials indicated that the EOs from Pelargonium graveolens and Zataria multiflora are potentially effective to treat oral candidiasis. Further nonclinical and clinical studies with these EO are warranted to determine their potential use and safety for the treatment of oral candidiasis.
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