Brain lipid concentrations in bipolar disorder.
Brain lipid concentrations in bipolar disorder.
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DOI：
10.1016/j.jpsychires.2009.08.001
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发表时间：
2010-02
影响因子：
4.8
通讯作者：
Rao JS
中科院分区：
文献类型：
--
作者：
Igarashi M;Ma K;Gao F;Kim HW;Greenstein D;Rapoport SI;Rao JS
双相情感障碍（BD）患者死后脑中二十二碳六烯酸（DHA，22：6n-3）和花生四烯酸（AA，20：4n-6）的浓度降低。此外，BD患病率的增加与鱼类饮食摄入量低有关，据报道，含有鱼类产品或DHA的膳食补充剂可改善BD症状。这些观察结果表明，脑脂质代谢，特别是涉及DHA，在BD中受到干扰。为了测试这一建议，不同的脂质浓度进行了测量，使用内部标准在死后额叶皮层从8 BD患者和6个匹配的控制。与对照皮质相比，BD皮质的"稳定"脂质（总脂质、总磷脂、单个磷脂或胆固醇）、未酯化脂肪酸或稳定脂质内酯化DHA或AA的平均浓度（每克湿重）无统计学显著差异。组间酯化AA和DHA分数浓度也无显著差异。低丰度胆固醇酯中发现了一些脂肪酸浓度差异。这些结果不支持BD患者脑脂质浓度（包括AA和DHA浓度）紊乱的假设。然而，正电子发射断层扫描可以用来观察大脑AA或DHA动力学是否在疾病中受到干扰。
Reduced concentrations of docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (AA, 20:4n-6) have been reported in the postmortem bipolar disorder (BD) brain. Additionally, an increased prevalence of BD has been related to low dietary intake of fish, and dietary supplements containing fish products or DHA have been reported to ameliorate BD symptoms. These observations suggest that brain lipid metabolism, particularly involving DHA, is disturbed in BD. To test this suggestion, concentrations of different lipids were measured using internal standards in postmortem frontal cortex from eight BD patients and six matched controls. Compared with control cortex, the BD cortex showed no statistically significant difference in mean concentrations (per gram wet weight) of “stable” lipids (total lipid, total phospholipid, individual phospholipids, or cholesterol), of unesterified fatty acids, or of esterified DHA or AA within stable lipids. Fractional esterified AA and DHA concentrations also did not differ significantly between groups. Some fatty acid concentration differences were found in low-abundant cholesteryl ester. These results do not support the hypothesis of disturbed brain lipid concentrations, including concentrations of AA and DHA, in BD. Positron emission tomography might be used, however, to see if brain AA or DHA kinetics are disturbed in the disease.
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