Dpp signaling inhibits proliferation in the Drosophila wing by Omb-dependent regional control of bantam
Dpp signaling inhibits proliferation in the Drosophila wing by Omb-dependent regional control of bantam
复制标题
Dpp 信号通过 Omb 依赖的 bantam 区域控制抑制果蝇翅膀的增殖
DOI：
10.1242/dev.094300
复制
发表时间：
2013-07
期刊：
影响因子：
4.6
通讯作者：
Shen, Jie
中科院分区：
文献类型：
--
作者：
Zhang, Xubo;Luo, Dan;Pflugfelder, Gert O;Shen, Jie
器官生长的控制是动物发育的一个基本方面，但人们对此知之甚少。长期以来，DPP一直被认为是果蝇翅膀发育过程中细胞增殖的一般促进剂。在翼形象盘中观察到的均匀的细胞增殖是否需要DPP梯度仍在争论中。在这里，我们研究了DPP信号通路如何在翅膀发育过程中调节增殖。通过对DPP信号的系统操作，我们观察到它以一种区域特异性的方式控制增殖：DPP通过OMB促进外侧盘的增殖，并抑制内翼盘的增殖。OMB通过反向调控内侧翼盘和外侧翼盘中microRNA基因BANTAM的转录来控制区域增殖速度。然而，DPP和OMB梯度都不是沿前后轴均匀增殖所必需的。
The control of organ growth is a fundamental aspect of animal development but remains poorly understood. The morphogen Dpp has long been considered as a general promoter of cell proliferation during Drosophila wing development. It is an ongoing debate whether the Dpp gradient is required for the uniform cell proliferation observed in the wing imaginal disc. Here, we investigated how the Dpp signaling pathway regulates proliferation during wing development. By systematic manipulation of Dpp signaling we observed that it controls proliferation in a region-specific manner: Dpp, via omb, promoted proliferation in the lateral and repressed proliferation in the medial wing disc. Omb controlled the regional proliferation rate by oppositely regulating transcription of the microRNA gene bantam in medial versus lateral wing disc. However, neither the Dpp nor Omb gradient was essential for uniform proliferation along the anteroposterior axis.
登录
查看更多内容
影响因子：
56.9
作者：
Shen, J;Dahmann, C
通讯作者：
Dahmann, C
影响因子：
2.7
作者：
BRYANT, PJ;LEVINSON, P
通讯作者：
LEVINSON, P
影响因子：
7.7
作者：
Doumpas, Nikolaos;Ruiz-Romero, Marina;Teleman, Aurelio A.
通讯作者：
Teleman, Aurelio A.
影响因子：
7.3
作者：
Baena-Lopez LA;Franch-Marro X;Vincent JP
通讯作者：
Vincent JP
影响因子：
2.7
作者：
Makoto Umemori;Masahiko Takemura;Kousuke Maeda;Keisuke Ohba;T. Adachi-Yamada
通讯作者：
Makoto Umemori;Masahiko Takemura;Kousuke Maeda;Keisuke Ohba;T. Adachi-Yamada