Intestinal microbiota in human health and disease: the impact of probiotics.
Intestinal microbiota in human health and disease: the impact of probiotics.
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DOI：
10.1007/s12263-011-0229-7
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发表时间：
2011-08
影响因子：
3.5
通讯作者：
de Vos, Willem M.
中科院分区：
文献类型：
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作者：
Gerritsen, Jacoline;Smidt, Hauke;Rijkers, Ger T.;de Vos, Willem M.
定植于人类胃肠道的复杂微生物群落在人类健康中起着重要作用。非培养分子技术的发展为肠道微生物群的组成和多样性提供了新的见解。在这里，我们总结了肠道菌群的最新技术水平，特别关注高通量功能性微生物组学方法的应用，以确定肠道菌群对人类健康的贡献。此外，我们还回顾了微生物群失调与肠道和肠外疾病之间的关系。最后，我们讨论了益生菌微生物调节肠道微生物群的潜力，从而有助于健康和福祉。益生菌消费对肠道微生物群的影响得到解决，以及定制的益生菌的开发设计与微生物生态失调相关的特定畸变。
The complex communities of microorganisms that colonise the human gastrointestinal tract play an important role in human health. The development of culture-independent molecular techniques has provided new insights in the composition and diversity of the intestinal microbiota. Here, we summarise the present state of the art on the intestinal microbiota with specific attention for the application of high-throughput functional microbiomic approaches to determine the contribution of the intestinal microbiota to human health. Moreover, we review the association between dysbiosis of the microbiota and both intestinal and extra-intestinal diseases. Finally, we discuss the potential of probiotic microorganism to modulate the intestinal microbiota and thereby contribute to health and well-being. The effects of probiotic consumption on the intestinal microbiota are addressed, as well as the development of tailor-made probiotics designed for specific aberrations that are associated with microbial dysbiosis.
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影响因子：
3.7
作者：
Biagi E;Nylund L;Candela M;Ostan R;Bucci L;Pini E;Nikkïla J;Monti D;Satokari R;Franceschi C;Brigidi P;De Vos W
通讯作者：
De Vos W
影响因子：
3.7
作者：
Armougom F;Henry M;Vialettes B;Raccah D;Raoult D
通讯作者：
Raoult D
影响因子：
3.6
作者：
Balamurugan, Ramadass;George, Gemlyn;Ramakrishna, Balakrishnan S.
通讯作者：
Ramakrishna, Balakrishnan S.
DOI：
10.1152/ajpgi.2001.280.5.g922
发表时间：
2001-05-01
影响因子：
4.5
作者：
Atuma, C;Strugala, V;Holm, L
通讯作者：
Holm, L
影响因子：
--
作者：
Aura, Anna-Marja;Mattila, Ismo;Oksman-Caldentey, Kirsi-Marja
通讯作者：
Oksman-Caldentey, Kirsi-Marja