Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.
Effects of Insomnia on Peptic Ulcer Disease Using Mendelian Randomization.
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使用孟德尔随机法研究失眠对消化性溃疡疾病的影响
DOI：
10.1155/2021/2216314
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发表时间：
2021
影响因子：
--
通讯作者：
Tu X
中科院分区：
文献类型：
--
作者：
Zha LF;Dong JT;Wang JL;Chen QW;Wu JF;Zhou YC;Nie SF;Tu X
观察性研究表明，失眠可能会增加患消化性溃疡病（PUD）的风险。我们的目的是通过孟德尔随机化分析来阐明失眠与PUD之间可能的因果关系。 我们使用失眠GWAS（N =高达1，331，010人）和PUD GWAS（N =高达456，327人）报告的遗传变异的汇总统计数据进行分析。采用三种孟德尔随机化方法探讨失眠是否可能在PUD中发挥因果作用，并进行途径和功能富集分析以预测潜在机制。 传统的孟德尔随机化分析显示失眠与PUD之间存在明确的因果关系; 1 SD失眠事件增加与PUD风险增加19%相关（P = 6.69 × 10−16; OR，1.19（95%CI，1.14-1.24））。在使用加权中位数法（P = 7.75 × 10−7; OR，1.16（95% CI，1.09-1.23））和MR-Egger回归（P = 5.00 × 10−3; OR，1.27（95% CI，1.07-1.50））进行的其他两项分析中，失眠与PUD之间的关联是一致的。此外，没有证据表明PUD事件和失眠症状之间存在反向因果关系。通路和功能富集分析表明，失眠可能通过免疫系统和氧化应激等多种途径影响PUD。 这项孟德尔随机化研究表明失眠是PUD的一个因果风险因素。可能的机制包括免疫和氧化应激。这些发现表明，改善睡眠质量可能对健康有重大益处。
Observational studies indicate that insomnia may increase risk of peptic ulcer disease (PUD). Our purpose is to clarify the possible causal relationship between insomnia and PUD by Mendelian randomization analyses. We carried out analyses using summary statistics data for genetic variants reported from a GWAS of insomnia (N = up to 1,331,010 individuals) and from a GWAS of PUD (N = up to 456,327 individuals). Three Mendelian randomization approaches were used to explore whether insomnia might play a causal role in PUD, and pathway and functional enrichment analyses were conducted to anticipate the underlying mechanisms. Conventional Mendelian randomization analysis showed clear causality between insomnia and PUD; 1 SD increased insomnia incident was related to a 19% higher risk of PUD (P = 6.69 × 10−16; OR, 1.19 (95% CI, 1.14-1.24)). The associations between insomnia and PUD were consistent in the other two analyses performed using the weighted median method (P = 7.75 × 10−7; OR, 1.16 (95% CI, 1.09-1.23)) and MR-Egger regression (P = 5.00 × 10−3; OR, 1.27 (95% CI, 1.07-1.50)). Moreover, no evidence indicated a reverse causality between PUD events and insomnia symptoms. Pathway and functional enrichment analyses indicated that the mechanisms of insomnia effect on PUD may be through various ways, such as the immune system and oxidative stress. This Mendelian randomization study suggests insomnia as a causal risk factor for PUD. The potential mechanisms included may be immune and oxidative stress. These findings indicate that improving sleep quality could have substantial health benefits.
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影响因子：
3.1
作者：
Alzoubi, Karem H.;Khabour, Omar F.;Abu Rashid, Baraa E.
通讯作者：
Abu Rashid, Baraa E.
影响因子：
7.5
作者：
Mahmoud, Yomna, I;Abd El-Ghffar, Eman A.
通讯作者：
Abd El-Ghffar, Eman A.
影响因子：
4.6
作者：
Fang, Boye;Yang, Shuyan;Chen, Gengzhen
通讯作者：
Chen, Gengzhen
影响因子：
16.6
作者：
Burgess, Stephen;Foley, Christopher N.;Howson, Joanna M. M.
通讯作者：
Howson, Joanna M. M.
DOI：
10.1016/s1098-3597(03)90031-7
发表时间：
2003-01-01
期刊：
Clinical cornerstone
影响因子：
--
作者：
Roth, Thomas;Roehrs, Timothy
通讯作者：
Roehrs, Timothy