Mechanisms of False Alarm in Response to Fear Stimulus: An Event-Related Potential Study.
Mechanisms of False Alarm in Response to Fear Stimulus: An Event-Related Potential Study.
复制标题
响应恐惧刺激的虚假警报机制：与事件相关的潜在研究。
DOI：
10.3389/fnhum.2021.730011
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发表时间：
2021
影响因子：
2.9
通讯作者：
Ma J
中科院分区：
文献类型：
--
作者：
Wang X;Sun J;Yang J;Cheng S;Liu C;Hu W;Ma J
有一个缺乏研究，探讨了“假警报”的机制。为了弥补这一认识上的不足，本研究采用事件相关电位（ERP）技术来揭示恐惧刺激引起的虚假警报的机制。本研究以蛇为实验材料，采用“古怪范式”模拟虚惊状态。通过比较真实的蛇和玩具蛇认知加工的异同，揭示了虚惊产生的机制。事件相关电位结果表明，在加工的早期阶段，真实的蛇和玩具蛇诱发的N1和P2成分无显著差异。与玩具蛇相比，真实的蛇在加工后期诱发的N2波幅较小，P3波幅较大，P3潜伏期较短。脑地形图分析结果表明，分别在110-150和220-270 ms的时间窗内，被一条真实的或玩具蛇激活的脑区基本相同。在300-360和400-500 ms的时间窗内，真实的蛇引起的脑区激活程度显著大于玩具蛇引起的脑区激活程度。假警报是由于大脑在认知过程的早期阶段无法区分具有相似外观的刺激对象而引起的。当大脑能够在认知处理的后期区分不同刺激对象之间的差异时，误报就会消失。
There is a paucity of research that has explored “False Alarm” mechanisms. In order to remedy this deficiency in knowledge, the present study used event-related potential (ERP) technology to reveal the mechanisms underlying False Alarm in response to fear stimuli. This study selected snakes as experimental materials and the “oddball paradigm” was used to simulate the conditions of False Alarm. The mechanism underlying False Alarm was revealed by comparing cognitive processing similarities and differences between real snakes and toy snakes. Event-related potential findings demonstrated that there was no significant difference between N1 and P2 components induced by real and toy snakes in the early processing stage. Compared with toy snakes, real snakes induced smaller N2 amplitude, larger P3 amplitude, and a shorter P3 latency at the late processing stage. The results of brain topographic mapping analysis showed that the brain regions activated by a real or toy snake were basically the same within the time windows of 110–150 and 220–270 ms, respectively. In the time window of 300–360 and 400–500 ms, the degree of brain regions activation with a real snake was significantly greater than that induced by a toy snake. False Alarm is caused by the brain’s inability to distinguish, in the early stage of cognitive processing, stimulus objects with similar appearances. When the brain is able to distinguish the differences between different stimulus objects in the late stage of cognitive processing, False Alarm disappears.
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影响因子：
4.4
作者：
Coelho CM;Polák J;Suttiwan P;Zsido AN
通讯作者：
Zsido AN
影响因子：
3
作者：
Dhamija, Devika;Tuvblad, Catherine;Baker, Laura A.
通讯作者：
Baker, Laura A.
影响因子：
6.4
作者：
Reinhard, Julia;Drepper, Carsten;Romanos, Marcel
通讯作者：
Romanos, Marcel
DOI：
10.1007/978-981-15-7086-5_1
发表时间：
2020-01-01
期刊：
NEURAL CIRCUITS OF INNATE BEHAVIORS
影响因子：
--
作者：
Ren, Chaoran;Tao, Qian
通讯作者：
Tao, Qian
DOI：
10.1176/appi.ajp.2009.09030410
发表时间：
2010-01
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Lissek S;Rabin S;Heller RE;Lukenbaugh D;Geraci M;Pine DS;Grillon C
通讯作者：
Grillon C