Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio).
Stress reactivity elicits a tissue-specific reduction in telomere length in aging zebrafish (Danio rerio).
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DOI：
10.1038/s41598-020-79615-1
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发表时间：
2021-01-11
影响因子：
4.6
通讯作者：
Brennan CH
中科院分区：
文献类型：
--
作者：
Evans JR;Torres-Pérez JV;Miletto Petrazzini ME;Riley R;Brennan CH
个性上的个体差异与健康老龄化的差异有关。健康行为经常被认为是这种联系的可能解释；然而，潜在的生物学机制也可能存在。加速的白细胞端粒缩短与多种年龄相关疾病有关，并与下丘脑-垂体-肾上腺(HPA)轴的慢性激活有关，在应激相关的个性差异和不良健康后果之间提供了联系。然而，HPA轴的影响是组织特有的。因此，在疾病相关组织中，白细胞端粒长度可能不能准确反映端粒长度。在这里，我们研究了年轻斑马鱼(6-9个月)和老化斑马鱼(18个月)心脏和脑组织应激反应与端粒长度之间的相关性。应激反应通过坦克潜水和基因表达来评估。用定量聚合酶链式反应测定端粒长度。我们发现老化的斑马鱼在心脏和大脑中都有较短的端粒。端粒长度与老年个体心脏的应激反应呈负相关，但与脑内的应激反应无关。这些数据支持这样的假设，即焦虑易感性导致心脏组织端粒加速缩短，这可能对我们理解年龄相关性心脏病具有重要意义，而应激反应以组织特异性的方式导致年龄相关端粒缩短。
Individual differences in personality are associated with variation in healthy aging. Health behaviours are often cited as the likely explanation for this association; however, an underlying biological mechanism may also exist. Accelerated leukocyte telomere shortening is implicated in multiple age-related diseases and is associated with chronic activation of the hypothalamus–pituitary–adrenal (HPA) axis, providing a link between stress-related personality differences and adverse health outcomes. However, the effects of the HPA axis are tissue specific. Thus, leukocyte telomere length may not accurately reflect telomere length in disease-relevant tissues. Here, we examined the correlation between stress reactivity and telomere length in heart and brain tissue in young (6–9 month) and aging (18 month) zebrafish. Stress reactivity was assessed by tank diving and through gene expression. Telomere length was assessed using quantitative PCR. We show that aging zebrafish have shorter telomeres in both heart and brain. Telomere length was inversely related to stress reactivity in heart but not brain of aging individuals. These data support the hypotheses that an anxious predisposition contributes to accelerated telomere shortening in heart tissue, which may have important implications for our understanding of age-related heart disease, and that stress reactivity contributes to age-related telomere shortening in a tissue-specific manner.
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影响因子：
2.4
作者：
Arslan-Ergul A;Adams MM
通讯作者：
Adams MM
影响因子：
3.7
作者：
Anchelin M;Murcia L;Alcaraz-Pérez F;García-Navarro EM;Cayuela ML
通讯作者：
Cayuela ML
影响因子：
3.3
作者：
Arslan-Ergul, Ayca;Erbaba, Begun;Adams, Michelle M.
通讯作者：
Adams, Michelle M.
影响因子：
--
作者：
D'Mello, Matthew J. J.;Ross, Stephanie A.;Pare, Guillaume
通讯作者：
Pare, Guillaume
影响因子：
15.1
作者：
Choi, Jenny;Fauce, Steven R.;Effros, Rita B.
通讯作者：
Effros, Rita B.