Fe(3)O(4)-Au Core-Shell Nanoparticles as a Multimodal Platform for In Vivo Imaging and Focused Photothermal Therapy.
Fe(3)O(4)-Au Core-Shell Nanoparticles as a Multimodal Platform for In Vivo Imaging and Focused Photothermal Therapy.
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DOI：
10.3390/pharmaceutics13030416
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发表时间：
2021-03-20
期刊：
影响因子：
5.4
通讯作者：
García-Martín ML
中科院分区：
文献类型：
--
作者：
Caro C;Gámez F;Quaresma P;Páez-Muñoz JM;Domínguez A;Pearson JR;Pernía Leal M;Beltrán AM;Fernandez-Afonso Y;De la Fuente JM;Franco R;Pereira E;García-Martín ML
在这项研究中，我们报道了用聚乙烯吡咯烷酮(Fe@Au NPs)包覆金包覆的氧化铁纳米颗粒的合成。所合成的纳米粒子(NPs)在水介质中具有良好的稳定性，作为磁共振成像(MRI)和X射线计算机断层扫描(CT)的造影剂(CA)具有良好的性能。此外，由于金的局部表面等离子体共振的存在，纳米粒子在近红外(NIR)区域显示出可利用的“光-热”转换能力，这是有效的光热疗法(PTT)的关键属性。体外实验表明，PTT具有良好的生物相容性和良好的杀伤胶质母细胞瘤细胞的能力。利用斑马鱼胚胎作为细胞和啮齿动物模型之间的中间步骤，证明了纳米颗粒在体内的无毒性。为了确保在肿瘤内获得有效的治疗剂量，通过MRI和CT在啮齿动物模型中对肿瘤内和静脉途径进行了筛选。药代动力学和生物分布证实了Fe@AuNPs的多模式成像CA能力，并揭示了肿瘤靶向的静脉途径的限制，决定了治疗应用的肿瘤内给药。最后，Fe@Au纳米粒子被成功地用于在小鼠模型中验证成像引导的聚焦PTT治疗多形性胶质母细胞瘤的概念。
In this study, we report the synthesis of gold-coated iron oxide nanoparticles capped with polyvinylpyrrolidone (Fe@Au NPs). The as-synthesized nanoparticles (NPs) exhibited good stability in aqueous media and excellent features as contrast agents (CA) for both magnetic resonance imaging (MRI) and X-ray computed tomography (CT). Additionally, due to the presence of the local surface plasmon resonances of gold, the NPs showed exploitable “light-to-heat” conversion ability in the near-infrared (NIR) region, a key attribute for effective photothermal therapies (PTT). In vitro experiments revealed biocompatibility as well as excellent efficiency in killing glioblastoma cells via PTT. The in vivo nontoxicity of the NPs was demonstrated using zebrafish embryos as an intermediate step between cells and rodent models. To warrant that an effective therapeutic dose was achieved inside the tumor, both intratumoral and intravenous routes were screened in rodent models by MRI and CT. The pharmacokinetics and biodistribution confirmed the multimodal imaging CA capabilities of the Fe@AuNPs and revealed constraints of the intravenous route for tumor targeting, dictating intratumoral administration for therapeutic applications. Finally, Fe@Au NPs were successfully used for an in vivo proof of concept of imaging-guided focused PTT against glioblastoma multiforme in a mouse model.
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影响因子：
4.6
作者：
Pham DH;De Roo B;Nguyen XB;Vervaele M;Kecskés A;Ny A;Copmans D;Vriens H;Locquet JP;Hoet P;de Witte PA
通讯作者：
de Witte PA
影响因子：
4.6
作者：
Efremova MV;Naumenko VA;Spasova M;Garanina AS;Abakumov MA;Blokhina AD;Melnikov PA;Prelovskaya AO;Heidelmann M;Li ZA;Ma Z;Shchetinin IV;Golovin YI;Kireev II;Savchenko AG;Chekhonin VP;Klyachko NL;Farle M;Majouga AG;Wiedwald U
通讯作者：
Wiedwald U
影响因子：
3.1
作者：
Caro, Carlos;Pozo, David
通讯作者：
Pozo, David
影响因子：
4.6
作者：
Gomez-Gonzalez, Elisabet;Nunez, Nuria O.;Ocana, Manuel
通讯作者：
Ocana, Manuel
聚乙二醇化 GdF3:Fe 纳米粒子作为多模态 T1/T2 加权 MRI 和 X 射线 CT 成像造影剂
影响因子：
9.5
作者：
Dong, Lile;Zhang, Peng;Zhang, Hongjie
通讯作者：
Zhang, Hongjie