Event-related potentials during visual target detection in treatment-naïve active alcoholics.
Event-related potentials during visual target detection in treatment-naïve active alcoholics.
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DOI：
10.1111/j.1530-0277.2011.01450.x
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发表时间：
2011-06
期刊：
影响因子：
--
通讯作者：
Andrew C
中科院分区：
文献类型：
--
作者：
Fein G;Andrew C
酗酒者视觉目标检测过程中 P3b 事件相关电位 (ERP) 振幅降低是一个明显的现象。然而，这一发现主要基于接受治疗的酗酒者样本，这些人仅占酗酒者的 25% 左右。我们研究了未接受治疗的酒精依赖样本 (TNAD) 与年龄和性别可比较的非酒精对照 (NAC) 中的视觉目标检测，以研究 P3 振幅降低是否普遍适用于 TNAD。在视觉目标检测过程中，记录了 74 个 TNAD 和 63 个年龄和性别相当的 NAC 的脑电图。在中线电极处应用方差分析来测量目标和罕见的非 43 目标条件下 N2 和 P3 ERP 分量的振幅和延迟。 TNAD 的 P3b 振幅稍低（p=0.05），N2b 振幅则明显较低（p=0.29）。在目标条件下，TNAD表现出P3b振幅的显着降低和N2b振幅的较大降低，这些现象彼此独立。 TNAD 中 P3b、N2b 和 P3a 的潜伏期早于 NAC，这种效应与我们报道的 TNAD 与 NAC 中更好的注意力效应相关。 TNAD 中 P3b 振幅的显着降低表明这种现象也存在于 TNAD 中，但显着小于在治疗样本中观察到的现象（我们报告在治疗的长期戒酒者中的效果是其 5 倍以上）。 N2b 幅度降低（长期戒酒者中不存在）可能反映了主动酗酒的影响。最后，TNAD 中这些成分的较短潜伏期与注意力测试中较好的得分相关，并且可能反映了主动饮酒情况下的补偿性注意力努力。
Reduced P3b event-related potentials (ERP) amplitude during visual target detection in alcoholics is a robust phenomenon. However, this finding is based primarily on samples of treated alcoholics, who comprise only about 25% of alcoholics. We studied visual target detection in a treatment-naïve alcohol dependent sample (TNAD) vs. age and gender comparable non-alcoholic controls (NAC) to investigate whether reduced P3 amplitudes generalize to TNAD. EEGs were recorded from 74 TNAD and 63 age and gender comparable NAC during visual target detection. ANOVA was applied at midline electrodes to amplitudes and latencies of N2 and P3 ERP components during target and rare non43 target conditions. TNAD had a modestly lower P3b amplitude (p=.05) and a more robustly lower N2b amplitude (p=0.29). In the target condition, TNAD showed a significant reduction in P3b amplitude and a larger reduction in N2b amplitude, with these phenomena being independent of each other. Latencies to P3b, N2b and P3a were earlier in TNAD than NAC, with this effect correlating with our reported effect of better attention in TNAD vs. NAC. The significant reduction of P3b amplitude in TNAD suggests that this phenomenon is present in TNAD, but dramatically smaller than that observed in treated samples (we reported an effect over 5 times as large in treated long-term abstinent alcoholics). The N2b amplitude reduction (not present in long-term abstinent alcoholics) may reflect the effects of active alcohol abuse. Finally, the shorter latencies of these components in TNAD is associated with better scores on tests of attention, and may reflect compensatory attentional effort in the context of active drinking.
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影响因子：
4.2
作者：
Di Sclafani, Victoria;Finn, Peter;Fein, George
通讯作者：
Fein, George
影响因子：
10.6
作者：
Kathmann, N;Soyka, M;Engel, RR
通讯作者：
Engel, RR
DOI：
10.1111/j.1530-0277.2007.00361.x
发表时间：
2007-05-01
影响因子：
3.2
作者：
Di Sclafani, Victoria;Finn, Peter;Fein, George
通讯作者：
Fein, George
影响因子：
5.7
作者：
Fein, George;Landman, Bennett;Moon, Kirk
通讯作者：
Moon, Kirk
影响因子：
10.6
作者：
Cohen, HL;Porjesz, B;Wang, WY
通讯作者：
Wang, WY