Coronary artery calcium incidence and changes using direct plaque measurements: The MASALA study.
Coronary artery calcium incidence and changes using direct plaque measurements: The MASALA study.
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DOI：
10.1016/j.atherosclerosis.2022.05.006
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发表时间：
2022-07
期刊：
影响因子：
5.3
通讯作者：
中科院分区：
文献类型：
--
作者：
我们的目的是确定南亚参与者冠状动脉钙（CAC）体积和密度的直接测量变化的预测因素。我们使用了生活在美国的南亚人动脉粥样硬化介质（MASALA）研究参与者的数据，这些参与者普遍存在CAC，并通过连续计算机断层扫描（CT）检查直接测量CAC（2010-2013年，2016-2018年）。我们在多变量模型中检查了事件CAC体积和峰值密度的分布，以及进展，并确定了体积和密度变化进展的危险因素。该研究队列包括102名发生CAC的参与者和285名CAC进展的参与者。CAC体积和密度最高，偶发性CAC以左前降支（LAD）最常见。右冠状动脉体积变化最大，左主干密度变化最大。在线性回归模型对CAC进展调整基线密度,体积,风险因素,吸烟(β+ 190.1,p = 0.02),基线卷(β+ 0.24 / mm3, p < 0.01),和扫描时间间隔(β+ 0.15,p = 0.01)与总量的变化而有关Lp (a)(β+ 0.81 mg / dL, p = 0.03),运动(β+ 0.19每10见到小敏/星期,p = 0.01),和基线卷(β+ 0.15 / mm3, p < 0.01)和密度(β−0.55单位,p < 0.01)与总密度的变化有关。在这个南亚队列中，吸烟与CAC体积进展有关，而Lp(a)和运动与CAC峰值密度进展有关。
We aimed to identify predictors of change in direct measures of coronary artery calcium (CAC) volume and density in South Asian participants. We used data from participants in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study with prevalent CAC and direct measures of CAC by serial computed tomography (CT) exams (2010–2013, 2016–2018). We examined the distribution of incident CAC volume and peak density, as well as progression and identified risk factors for progression of change in volume and density in multivariable models. The study cohort consisted of 102 participants with incident CAC and 285 with CAC progression. CAC volume and density were highest, and incident CAC was most common in the left anterior descending artery (LAD). The greatest progression in volume was in the right coronary artery and the greatest change in density was in the left main. In linear regression models for CAC progression adjusted for baseline density, volume, risk factors, smoking (β +190.1, p = 0.02), baseline volume (β +0.24 per mm3, p < 0.01), and scan interval (β +0.15 per day, p = 0.01) were associated with change in total volume whereas Lp(a) (β +0.81 per mg/dL, p = 0.03), exercise (β +0.19 per 10 MET-min/week, p = 0.01), and baseline volume (β +0.15 per mm3, p < 0.01) and density (β −0.55 per unit, p < 0.01) were associated with change in total density. In this South Asian cohort, smoking was associated with CAC volume progression, while Lp(a) and exercise were associated with progression of peak CAC density.
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