The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor.
The relationship between novelty-seeking traits and behavior: Establishing construct validity for the human Behavioral Pattern Monitor.
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DOI：
10.1016/j.psychres.2022.114776
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发表时间：
2022-10
影响因子：
11.3
通讯作者：
Perry, William
中科院分区：
文献类型：
--
作者：
Minassian, Arpi;Kelsoe, John R.;Miranda, Alannah;Young, Jared W.;Perry, William
新奇寻求是一种接近新情况的倾向，由大脑的儿茶酚胺能系统驱动。它传统上是通过自我报告来测量的，但基于实验室的范式，人类行为模式监测器（hBPM），量化了新环境中的行为，并在神经精神疾病的跨物种研究中具有实用性。我们的主要目的是评估自我报告的新奇寻求特质是否与hBPM中的新奇寻求行为相关。现有的样本106名志愿者被归类为高与低新奇寻求者使用气质和性格量表（TCI）。受试者被随机分配到一个剂量的安非他明（10或20毫克）或莫达非尼（200或400毫克），使我们能够探索药理学儿茶酚胺挑战是否进一步增强新奇寻求行为。高TCI新奇寻求者有更多的hBPM运动活动和新的物体互动。探索性分析，虽然有限的低功率，表明安非他明和莫达非尼没有显着温和的新奇寻求特征。hBPM证明了结构效度作为一种基于实验室的新奇寻求措施，因此在神经精神疾病和治疗方案的转化研究中很有用。进一步的研究可能会阐明，是否对较高的儿茶酚胺能活性的生物易感性，结合新奇的追求特质，可能会增加倾向的危险和成瘾行为。
Novelty seeking is a tendency to approach new situations, putatively driven by the brain’s catecholaminergic system. It is traditionally measured via self-report, but a laboratory-based paradigm, the human Behavioral Pattern Monitor (hBPM), quantifies behavior in a novel environment and has utility in cross-species studies of neuropsychiatric disorders. Our primary aim assessed whether self-reported novelty-seeking traits were associated with novelty-seeking behavior in the hBPM. An existing sample of 106 volunteers were categorized as high vs. low novelty seekers using the Temperament and Character Inventory (TCI). Subjects had been randomized to one dose of amphetamine (10 or 20 mg) or modafinil (200 or 400 mg), allowing us to explore whether a pharmacological catecholamine challenge further enhanced novelty-seeking behavior. High TCI novelty-seekers had more hBPM motor activity and novel object interactions. The exploratory analyses, although limited by low power, suggested that amphetamine and modafinil did not markedly moderate novelty-seeking traits. The hBPM demonstrates construct validity as a lab-based measure of novelty seeking and thus useful in translational studies of neuropsychiatric conditions and treatment options. Further research may illuminate whether a biological predisposition towards higher catecholaminergic activity, combined with the novelty-seeking trait, may increase propensity for risky and addictive behaviors.
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影响因子：
11.3
作者：
Perry, William;Minassian, Arpi;Henry, Brook;Kincaid, Meegin;Young, Jared W.;Geyer, Mark A.
通讯作者：
Geyer, Mark A.
影响因子：
2.7
作者：
Henry, Brook L.;Geyer, Mark A.;Buell, Mahalah;Perry, William;Young, Jared W.;Minassian, Arpi
通讯作者：
Minassian, Arpi
影响因子：
25
作者：
Cohen, Michael X.;Schoene-Bake, Jan-Christoph;Weber, Bernd
通讯作者：
Weber, Bernd
影响因子：
11.3
作者：
Garvey, MJ;Noyes, R;Blum, N
通讯作者：
Blum, N
影响因子：
16.2
作者：
Bunzeck, Nico;Duzel, Emrah
通讯作者：
Duzel, Emrah