Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease.
Spatio-temporal dynamics of cortical drive to human subthalamic nucleus neurons in Parkinson's disease.
复制标题
DOI：
10.1016/j.nbd.2018.01.001
复制
发表时间：
2018-04
影响因子：
6.1
通讯作者：
Engel AK
中科院分区：
文献类型：
--
作者：
Sharott A;Gulberti A;Hamel W;Köppen JA;Münchau A;Buhmann C;Pötter-Nerger M;Westphal M;Gerloff C;Moll CKE;Engel AK
丘脑下核（STN）和大脑皮层之间的β频率（12-35 Hz）振荡的病理同步被认为是帕金森病（PD）运动障碍的原因之一。这种皮层-丘脑下振荡驱动在机制上是重要的，它必须影响STN神经元的放电，从而影响它们的下游目标。在这里，我们研究了在休息和运动期间，STN lfp和具有多个皮质区域的单元之间的同步动态，使用额叶脑电图、中线脑电图和侧边脑电图进行测量。STN神经元滞后于中线（运动前皮层）和额叶（前额叶皮层）记录的皮质信号，具有稳定的时间延迟，与强皮层-丘脑下驱动一致，并且许多神经元在运动过程中保持这些动态。相比之下，大多数STN神经元在运动过程中与侧脑电图信号（在初级运动皮层上）失同步，而那些没有与皮层信号发生相位关系改变的神经元。STN单元和中线脑电图在高β范围（25-35 Hz）的同步强度与患者的动力刚性运动症状的严重程度呈正相关。总之，这些结果表明，STN神经元与运动前皮层β振荡的持续同步在破坏PD正常运动编码中起重要作用。同时记录STN单单元和局部场电位的多通道脑电图。不同皮质区和STN神经元的β振荡之间存在可变时滞。额叶/运动前皮质区与STN神经元具有最稳定的振荡同步。皮质-丘脑下-频率同步与PD临床评分的相关性。
Pathological synchronisation of beta frequency (12–35 Hz) oscillations between the subthalamic nucleus (STN) and cerebral cortex is thought to contribute to motor impairment in Parkinson's disease (PD). For this cortico-subthalamic oscillatory drive to be mechanistically important, it must influence the firing of STN neurons and, consequently, their downstream targets. Here, we examined the dynamics of synchronisation between STN LFPs and units with multiple cortical areas, measured using frontal ECoG, midline EEG and lateral EEG, during rest and movement. STN neurons lagged cortical signals recorded over midline (over premotor cortices) and frontal (over prefrontal cortices) with stable time delays, consistent with strong corticosubthalamic drive, and many neurons maintained these dynamics during movement. In contrast, most STN neurons desynchronised from lateral EEG signals (over primary motor cortices) during movement and those that did not had altered phase relations to the cortical signals. The strength of synchronisation between STN units and midline EEG in the high beta range (25–35 Hz) correlated positively with the severity of akinetic-rigid motor symptoms across patients. Together, these results suggest that sustained synchronisation of STN neurons to premotor-cortical beta oscillations play an important role in disrupting the normal coding of movement in PD. Multi-channel EEG with coincident STN single unit and local field potential recordings Variable time delays between beta oscillations in different cortical areas and STN neurons. Frontal/premotor cortical areas have most stable oscillatory synchronisation with STN neurons. Correlation between cortico-subthalamic beta-frequency synchronisation and clinical scores in PD.
登录
查看更多内容
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.7
作者：
Devos, D.;Szurhaj, W.;Defebvre, L.
通讯作者：
Defebvre, L.
影响因子：
16.2
作者：
Do, MTH;Bean, BP
通讯作者：
Bean, BP
影响因子：
5.3
作者：
Chen, Chiung Chu;Hsu, Yi Ting;Brown, Peter
通讯作者：
Brown, Peter
DOI：
10.1523/jneurosci.5717-11.2012
发表时间：
2012-04-25
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kita T;Kita H
通讯作者：
Kita H