Photosynthetic entrainment of the Arabidopsis thaliana circadian clock.
Photosynthetic entrainment of the Arabidopsis thaliana circadian clock.
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昼夜节律时钟通过驱动细菌、真菌、植物和动物的行为、生理和新陈代谢的日常节律，在深受地球自转影响的环境中提供竞争优势。昼夜节律钟由转录-翻译反馈环路组成，这些环路受到光和温度等环境信号的影响，以调整节律的相位以匹配当地环境。通过光合作用产生糖是植物生物钟的关键代谢产物。在这里，我们发现这些有节奏的内源性糖信号可以通过在光周期早期调节生物钟成分的基因表达来控制拟南芥的昼夜节律，从而定义“代谢黎明”。通过抑制光合作用，我们证明糖水平的内源振荡通过早晨表达的基因伪响应调节器7（PRR7）向昼夜节律振荡器提供代谢反馈，并且我们发现prr7突变体对蔗糖对昼夜节律的影响不敏感。因此，光合作用对A中稳健的昼夜节律的形成和维持具有显着影响。拟南芥，证明新陈代谢在生物钟的调节中起着至关重要的作用。
Circadian clocks provide a competitive advantage in an environment that is heavily influenced by the rotation of the Earth,, by driving daily rhythms in behaviour, physiology and metabolism in bacteria, fungi, plants and animals,. Circadian clocks comprise transcription–translation feedback loops, which are entrained by environmental signals such as light and temperature to adjust the phase of rhythms to match the local environment. The production of sugars by photosynthesis is a key metabolic output of the circadian clock in plants,. Here we show that these rhythmic, endogenous sugar signals can entrain circadian rhythms inArabidopsis thalianaby regulating the gene expression of circadian clock components early in the photoperiod, thus defining a ‘metabolic dawn’. By inhibiting photosynthesis, we demonstrate that endogenous oscillations in sugar levels provide metabolic feedback to the circadian oscillator through the morning-expressed genePSEUDO-RESPONSE REGULATOR 7(PRR7), and we identify thatprr7mutants are insensitive to the effects of sucrose on the circadian period. Thus, photosynthesis has a marked effect on the entrainment and maintenance of robust circadian rhythms inA. thaliana, demonstrating that metabolism has a crucial role in regulation of the circadian clock.
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影响因子：
56.9
作者：
Harmer, SL;Hogenesch, LB;Kay, SA
通讯作者：
Kay, SA
FINS1/FBP在拟南芥中介导的果糖的信号传导作用。
影响因子：
4.5
作者：
Cho YH;Yoo SD
通讯作者：
Yoo SD
影响因子：
56.9
作者：
LEUNG, J;BOUVIERDURAND, M;GIRAUDAT, J
通讯作者：
GIRAUDAT, J
影响因子：
56.9
作者：
James, Allan B.;Monreal, Jose A.;Nimmo, Hugh G.
通讯作者：
Nimmo, Hugh G.
影响因子：
7.2
作者：
Hudson, ME;Lisch, DR;Quail, PH
通讯作者：
Quail, PH