Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy.
Autoantibody targets and their cancer relationship in the pathogenicity of paraneoplastic retinopathy.
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自身抗体靶标及其在副肿瘤性视网膜病的致病性中的癌症关系。
DOI：
10.1016/j.autrev.2009.01.002
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发表时间：
2009-03
影响因子：
13.6
通讯作者：
Adamus, Grazyna
中科院分区：
文献类型：
--
作者：
Adamus, Grazyna
副肿瘤视网膜病变（PR），包括癌症相关视网膜病变（CAR）或密切相关的黑色素瘤相关视网膜病变（MAR）发生在一小部分视网膜变性和系统性癌症患者中。这种自身免疫性综合征的特点是与循环抗视网膜自身抗体相关的突然进行性视力丧失。PR综合征是异质性的，可能产生多种眼部症状，并可能与几种不同的肿瘤相关，包括肺癌、乳腺癌、前列腺癌、妇科、结肠癌、黑色素瘤和血液系统恶性肿瘤。我们检查了视网膜病变的发病与癌症诊断和PR患者特异性抗视网膜自身抗体的存在的相关性。在一些未确诊为恶性肿瘤的患者中，眼部症状的出现和自身抗体的存在早于癌症诊断数月至数年，包括抗恢复蛋白抗体、抗转导蛋白-α抗体和抗碳酸酐酶II抗体。虽然抗视网膜自身抗体可能不能很好地预测特定肿瘤，但它们可以作为不同亚型视网膜病变的生物标志物。鉴定参与自身免疫介导的PR的自身抗体将有助于阐明PR综合征的机制，并开发针对这些视力威胁疾病的靶向治疗方法。
Paraneoplastic retinopathies (PR), including cancer-associated retinopathy (CAR) or the closely related melanoma-associated retinopathy (MAR) occur in a small subset of patients with retinal degeneration and systemic cancer. This autoimmune syndrome is characterized by sudden, progressive loss of vision in association with circulating anti-retinal autoantibodies. The PR syndromes are heterogeneous, may produce a number of ocular symptoms, and may be associated with several different neoplasms, including lung, breast, prostate, gynecological, and colon cancer, melanoma, and hematologic malignancies. We examined the onset of retinopathy in correlation to the diagnosis of cancer and the presence of specific anti-retinal autoantibodies in PR patients. In some patients without diagnosed malignant tumors, the onset of ocular symptoms and the presence of autoantibodies preceded the diagnosis of cancer by months to years, including anti-recoverin, anti-transducin-α, and anti-carbonic anhydrase II antibodies. Although anti-retinal autoantibodies may not be a good predictor of a specific neoplasm, they can be used as biomarkers for different subtypes of retinopathy. Identification of autoantibodies involved in autoimmune-mediated PR will help elucidate the mechanisms underlying the PR syndromes and develop targeted therapies for these sight-threatening disorders.
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影响因子：
5.3
作者：
Bazhin, AV;Savchenko, MS;Philippov, PP
通讯作者：
Philippov, PP
影响因子：
5.3
作者：
Kobayashi, Makoto;Ikezoe, Takayuki;Taguchi, Hirokuni
通讯作者：
Taguchi, Hirokuni
影响因子：
11.2
作者：
Pittock, SJ;Kryzer, TJ;Lennon, VA
通讯作者：
Lennon, VA
影响因子：
12.8
作者：
Adamus, G;Machnicki, M;Fox, DA
通讯作者：
Fox, DA
影响因子：
2.2
作者：
Ohguro, H;Odagiri, H;Nakazawa, M
通讯作者：
Nakazawa, M