White matter integrity linked to functional impairments in aging and early Alzheimer's disease.
White matter integrity linked to functional impairments in aging and early Alzheimer's disease.
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DOI：
10.1016/j.jalz.2008.07.001
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发表时间：
2008-11
影响因子：
14
通讯作者：
Duffy, Charles J.
中科院分区：
文献类型：
--
作者：
Kavcic, Voyko;Ni, Hongyan;Zhu, Tong;Zhong, Jianhui;Duffy, Charles J.
阿尔茨海默病（AD）与脑白质（WM）的改变有关，但这些发现的功能意义尚未确定。我们假设弥散张量成像（DTI）可能揭示了早期AD患者局部WM变化与特定神经心理学和心理物理学定义的损伤之间的联系。老年对照者（OA, n=18）和轻度受损AD患者（n=14）进行神经心理学和视觉感知测试，并进行脑WM DTI测试。DTI获得了三个脑区9个roi的派系各向异性（FA）和平均扩散率（<D>）图，然后将其与性能测量进行比较。AD患者后区胼胝体和皮层下roi的FAs降低趋势不显著。然而，胼胝体后部FA与言语流畅性和图形记忆障碍显著相关，而皮质下后部FA与延迟言语记忆、图形记忆和光流知觉障碍相关。早期AD的WM变化集中在大脑后部，其分布与特定的功能损伤相对应。DTI可用于评估与早期AD个体缺陷相关的局部病理。
Alzheimer’s disease (AD) is associated with changes in cerebral white matter (WM) but the functional significance of such findings is not yet established. We hypothesized that diffusion tensor imaging (DTI) might reveal links between regional WM changes and specific neuropsychologically and psychophysically defined impairments in early AD. Older adult control subjects (OA, n=18) and mildly impaired AD patients (n=14) underwent neuropsychological and visual perceptual testing along with DTI of cerebral WM. DTI yielded factional anisotropy (FA) and mean diffusivity (<D>) maps for nine ROIs in three brain regions that were then compared to the performance measures. AD patients showed non-significant trends toward lower FAs in the posterior region’s callosal and sub-cortical ROIs. However, posterior callosal FA was significantly correlated with verbal fluency and figural memory impairments, whereas posterior subcortical FA was correlated with delayed verbal memory, figural memory, and optic flow perceptual impairments. WM changes in early AD are concentrated in posterior cerebral areas with distributions that correspond to specific functional impairments. DTI can be used to assess regional pathology related to individual’s deficits in early AD.
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影响因子：
4.2
作者：
Fellgiebel, A;Müller, MJ;Stoeter, P
通讯作者：
Stoeter, P
DOI：
10.1073/pnas.0308627101
发表时间：
2004-03-30
影响因子：
11.1
作者：
Greicius, MD;Srivastava, G;Menon, V
通讯作者：
Menon, V
影响因子：
3.7
作者：
Arnold, Steven E.;Hyman, Bradley T.;Van Hoesen, Gary W.
通讯作者：
Van Hoesen, Gary W.
影响因子：
6.4
作者：
BRUN, A;ENGLUND, E
通讯作者：
ENGLUND, E
影响因子：
5.3
作者：
Grady, CL;McIntosh, AR;Black, SE
通讯作者：
Black, SE