Re-thinking the role of motor cortex: context-sensitive motor outputs?
Re-thinking the role of motor cortex: context-sensitive motor outputs?
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DOI：
10.1016/j.neuroimage.2014.01.011
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发表时间：
2014-05-01
期刊：
影响因子：
5.7
通讯作者：
Ward NS
中科院分区：
文献类型：
--
作者：
Gandolla M;Ferrante S;Molteni F;Guanziroli E;Frattini T;Martegani A;Ferrigno G;Friston K;Pedrocchi A;Ward NS
运动控制的标准解释认为初级运动皮层（M1）的下行输出是运动命令和传出复制。这种解释最近受到了另一种主动推理的挑战：M1被认为是感觉运动层次结构的一部分，提供自上而下的本体感受预测。这些解释之间的关键区别在于，预测对当前的本体感受背景敏感，而传出复制则不然。使用功能性电刺激实验操纵本体感觉在自愿运动在健康的人类受试者，我们评估了上下文敏感的输出从M1的证据。功能磁共振成像反应的动态因果模型表明，FES改变本体感觉增加了M1对初级躯体感觉皮层（S1）的影响。这些结果消除了运动控制的竞争帐户，提供了一些深入了解的感觉衰减的突触机制，并可能发言的潜在机制的FES在促进运动神经康复学习的行动。外周功能性电刺激提供改变的本体感受。M1和S1显示了本体感觉和意志运动相互作用的改变。M1-S1连接受本体感受调节，因此是上下文敏感的。上下文敏感的M1-S1通路支持主动推理运动控制帐户。
The standard account of motor control considers descending outputs from primary motor cortex (M1) as motor commands and efference copy. This account has been challenged recently by an alternative formulation in terms of active inference: M1 is considered as part of a sensorimotor hierarchy providing top–down proprioceptive predictions. The key difference between these accounts is that predictions are sensitive to the current proprioceptive context, whereas efference copy is not. Using functional electric stimulation to experimentally manipulate proprioception during voluntary movement in healthy human subjects, we assessed the evidence for context sensitive output from M1. Dynamic causal modeling of functional magnetic resonance imaging responses showed that FES altered proprioception increased the influence of M1 on primary somatosensory cortex (S1). These results disambiguate competing accounts of motor control, provide some insight into the synaptic mechanisms of sensory attenuation and may speak to potential mechanisms of action of FES in promoting motor learning in neurorehabilitation. Peripheral functional electrical stimulation provides altered proprioception. Altered proprioception and volitional movement interaction is shown in M1 and S1. M1–S1 connection is modulated by proprioception and therefore is context-sensitive. Context-sensitive M1–S1 pathway supports an active inference motor control account.
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影响因子：
2.5
作者：
COHEN, DAD;PRUDHOMME, MJL;KALASKA, JF
通讯作者：
KALASKA, JF
影响因子：
2.9
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2
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通讯作者：
Roman, GL