Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods.
Comparative genomics analysis of triatomines reveals common first line and inducible immunity-related genes and the absence of Imd canonical components among hemimetabolous arthropods.
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三局素的比较基因组学分析揭示了半代谢节肢动物之间常见的第一线和可诱导的免疫相关基因以及IMD规范成分的不存在。
DOI：
10.1186/s13071-017-2561-2
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发表时间：
2018-01-22
影响因子：
3.2
通讯作者：
Rodríguez MH
中科院分区：
文献类型：
--
作者：
Zumaya-Estrada FA;Martínez-Barnetche J;Lavore A;Rivera-Pomar R;Rodríguez MH
昆虫运用复杂的体液和细胞免疫策略来抵御入侵的微生物。其中大多数在果蝇和其他双翅目动物中都有特征。关于半翅虫，包括恰加斯病的锥蝽病媒的信息仍然不完整和零散。我们利用基于已建立的免疫应答基因参考的比较转录组学，结合预测的prodnius、Cimex lecticularis和Acyrthosiphon pisum半代谢蛋白质组学，鉴定了恰加斯病三种triatomae载体——Triatoma pallidipennis、T. dimidiata和T. infestans （TTTs）的推定免疫相关同源物。我们提出了这些ttt的体液和细胞固有免疫成分的压缩描述，并扩展了其他相关半球细胞的免疫信息。在所有被研究的半足动物中鉴定出了组成免疫基因和诱导免疫基因的关键同源物。我们在ttt中的结果扩展了之前在其他缺乏Imd信号通路成分的半胱氨酸的观察结果。与其他六足动物比较，使用已发表的数据，揭示了各种Imd规范成分的缺失在一些半代谢物种中是常见的。本文的在线版本（10.1186/s13071-017-2561-2）包含补充材料，授权用户可使用。
Insects operate complex humoral and cellular immune strategies to fend against invading microorganisms. The majority of these have been characterized in Drosophila and other dipterans. Information on hemipterans, including Triatominae vectors of Chagas disease remains incomplete and fractionated. We identified putative immune-related homologs of three Triatominae vectors of Chagas disease, Triatoma pallidipennis, T. dimidiata and T. infestans (TTTs), using comparative transcriptomics based on established immune response gene references, in conjunction with the predicted proteomes of Rhodnius prolixus, Cimex lecticularis and Acyrthosiphon pisum hemimetabolous. We present a compressive description of the humoral and cellular innate immune components of these TTTs and extend the immune information of other related hemipterans. Key homologs of the constitutive and induced immunity genes were identified in all the studied hemipterans. Our results in the TTTs extend previous observations in other hemipterans lacking several components of the Imd signaling pathway. Comparison with other hexapods, using published data, revealed that the absence of various Imd canonical components is common in several hemimetabolous species. The online version of this article (10.1186/s13071-017-2561-2) contains supplementary material, which is available to authorized users.
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影响因子：
6.7
作者：
Binggeli O;Neyen C;Poidevin M;Lemaitre B
通讯作者：
Lemaitre B
影响因子：
3.4
作者：
Bae YA;Cai GB;Kim SH;Zo YG;Kong Y
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Kong Y
影响因子：
3.8
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Cao X;He Y;Hu Y;Zhang X;Wang Y;Zou Z;Chen Y;Blissard GW;Kanost MR;Jiang H
通讯作者：
Jiang H
影响因子：
3.5
作者：
Chetia, Hasnahana;Kabiraj, Debajyoti;Bora, Utpal
通讯作者：
Bora, Utpal
影响因子：
2
作者：
Balczun, C.;Knorr, E.;Schaub, G. A.
通讯作者：
Schaub, G. A.