Language impairment in progressive supranuclear palsy and corticobasal syndrome.
Language impairment in progressive supranuclear palsy and corticobasal syndrome.
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DOI：
10.1007/s00415-019-09463-1
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发表时间：
2021-03
影响因子：
6
通讯作者：
Rowe JB
中科院分区：
文献类型：
--
作者：
Peterson KA;Patterson K;Rowe JB
虽然通常被称为运动障碍，但进行性核上性麻痹（PSP）和皮质基底动脉综合征（CBS）可能会伴随运动症状甚至在运动症状之前出现言语和语言的变化。这两种疾病的鉴别诊断可能具有挑战性，特别是在早期阶段。在这里，我们回顾了它们对言语和语言的影响。我们讨论了PSP和CBS的神经生物学和临床现象学重叠，以及与其他疾病，包括非流利的语法缺失型原发性进行性失语症和原发性进行性言语失用症。由于语言障碍通常是CBS和PSP的早期和持续性问题，因此需要改进初级和二级护理中的语言筛查方法，并在三级医疗环境中进行更详细的语言评估。改进的语言评估可以帮助鉴别诊断，并为临床管理决策提供信息。
Although commonly known as movement disorders, progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) may present with changes in speech and language alongside or even before motor symptoms. The differential diagnosis of these two disorders can be challenging, especially in the early stages. Here we review their impact on speech and language. We discuss the neurobiological and clinical-phenomenological overlap of PSP and CBS with each other, and with other disorders including non-fluent agrammatic primary progressive aphasia and primary progressive apraxia of speech. Because language impairment is often an early and persistent problem in CBS and PSP, there is a need for improved methods for language screening in primary and secondary care, and more detailed language assessments in tertiary healthcare settings. Improved language assessment may aid differential diagnosis as well as inform clinical management decisions.
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