Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.
Chemoattraction of progenitor cells by remodeling extracellular matrix scaffolds.
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DOI：
10.1089/ten.tea.2008.0162
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发表时间：
2009-05
影响因子：
--
通讯作者：
Badylak SF
中科院分区：
文献类型：
--
作者：
Beattie AJ;Gilbert TW;Guyot JP;Yates AJ;Badylak SF
在跟腱重建的小鼠模型中，评价了由细胞外基质（ECM）组成并经历体内降解和重塑的生物支架的趋化特性。在C57 BL/6和MRL/MpJ小鼠中的跟腱节段性切除后，用由膀胱基质（UBM）组成的ECM支架或切除的自体肌腱修复缺损。手术后3、7和14天，从每只动物中收获手术修复的肌腱和对侧肌腱。使用基于荧光的细胞迁移测定来量化多潜能祖细胞对收获的组织的趋化性。结果显示，在MRL/MpJ和C57 BL/6小鼠中，与用自体组织修复的肌腱和正常对侧肌腱相比，祖细胞向用UBM-ECM支架修复的肌腱的迁移更大。两种小鼠品系之间的趋化反应的幅度和时间模式不同。
The chemotactic properties of a biologic scaffold composed of extracellular matrix (ECM) and subjected to in vivo degradation and remodeling were evaluated in a mouse model of Achilles tendon reconstruction. Following a segmental resection of the Achilles tendon in both C57BL/6 and MRL/MpJ mice, the defect was repaired with either an ECM scaffold composed of urinary bladder matrix (UBM) or resected autologous tendon. The surgically repaired and the contralateral tendons were harvested at 3, 7, and 14 days following surgery from each animal. Chemotaxis of multipotential progenitor cells toward the harvested tissue was quantified using a fluorescent-based cell migration assay. Results showed greater migration of progenitor cells toward tendons repaired with UBM–ECM scaffold compared to both the tendons repaired with autologous tissue and the normal contralateral tendon in both the MRL/MpJ and C57BL/6 mice. The magnitude and temporal pattern of the chemotactic response differed between the two mouse strains.
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影响因子：
--
作者：
Cobb, MA;Badylak, SF;Boop, FA
通讯作者：
Boop, FA
DOI：
10.1002/jbm.820290714
发表时间：
1995-07-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
HILES, MC;BADYLAK, SF;MORFF, RJ
通讯作者：
MORFF, RJ
DOI：
10.1080/10623320490512390
发表时间：
2004-05-01
影响因子：
--
作者：
Li, F;Li, W;Badylak, SF
通讯作者：
Badylak, SF
影响因子：
14
作者：
Freytes, DO;Badylak, SF;Rundell, AE
通讯作者：
Rundell, AE
影响因子：
2.2
作者：
Badylak, SF;Vorp, DA;Nieponice, A
通讯作者：
Nieponice, A