Temporal instability in brain activation: a novel paradigm for evaluating the maintenance of attention among substance dependent patients.
Temporal instability in brain activation: a novel paradigm for evaluating the maintenance of attention among substance dependent patients.
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DOI：
10.1007/s00213-021-05909-5
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发表时间：
2021-10
影响因子：
3.4
通讯作者：
Bauer, Lance O.
中科院分区：
文献类型：
--
作者：
Bauer, Lance O.
关键词：
先前的研究表明，有物质依赖史（SD）的患者和对照组之间的脑功能存在统计学显著但细微的差异。本研究的目的是表明，在大脑激活的认知任务的试验的变化是更有用的揭示SD的推定的影响比分析集中在激活的幅度平均超过试验。该研究还测试了反社会人格障碍（ASPD）的额外贡献-一种普遍的合并症，促进了SD的早期发作和更严重的过程。211名成年人在完成两种选择性注意任务的同时记录了P300事件相关脑电。他们被分配到3个相互排斥的组之一：没有SD或ASPD的终身病史（n = 67），有SD病史但没有ASPD（n = 68），或SD和ASPD（n = 76）。主要发现是SD + ASPD组的P300振幅试验间变异性（ITV）与无任何属性的组相比有统计学显著性升高。在两个选择性注意任务中都检测到了这种升高，并且在位于额叶上方的电极部位最为突出。试验期间平均P300振幅无组间差异。因此，P300波幅的ITV是一种有效的、敏感的注意力维持的生物标志物。这对揭示物质依赖和反社会人格障碍的群体差异具有重要意义。它最终可能对检测精神兴奋剂治疗或其他干预措施（包括认知补救）所带来的改善很有价值。
Prior studies have demonstrated statistically significant but subtle differences in brain function between patients with a history of substance dependence (SD) and control groups. The goal of the present study was to show that variability in brain activation over the trials of a cognitive task is more useful for revealing the putative impact of SD than analyses focusing on the amplitude of activation averaged over trials. The study also tested the additional contribution of antisocial personality disorder (ASPD)—a prevalent comorbidity that promotes both an early onset and more severe course of SD. Two hundred eleven adults performed two selective attention tasks while P300 event-related electroencephalo-graphic potentials were recorded. They were assigned to one of 3 mutually exclusive groups: no lifetime history of SD or ASPD (n = 67), a SD history but no ASPD (n = 68), or both SD and ASPD (n = 76). The major finding was a statistically significant elevation of P300 amplitude inter-trial variability (ITV) in the SD plus ASPD group in comparison to the group with neither attribute. The elevation was detected during both selective attention tasks and most prominent at electrodes sites located over the frontal brain. There were no group differences in P300 amplitude averaged over trials. We conclude from these findings that the ITV of P300 amplitude is an efficient and sensitive biomarker of the maintenance of attention. It is valuable for revealing group differences associated with substance dependence and ASPD. It may ultimately be valuable for detecting improvements resulting from psychostimulant treatment or other interventions, including cognitive remediation.
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DOI：
10.1002/advs.202003395
发表时间：
2021-05
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
--
作者：
Clemen R;Freund E;Mrochen D;Miebach L;Schmidt A;Rauch BH;Lackmann JW;Martens U;Wende K;Lalk M;Delcea M;Bröker BM;Bekeschus S
通讯作者：
Bekeschus S
影响因子：
4.2
作者：
Costa, L;Bauer, L
通讯作者：
Bauer, L
DOI：
10.1016/0168-5597(84)90016-9
发表时间：
1984-01-01
期刊：
ELECTROENCEPHALOGRAPHY AND CLINICAL NEUROPHYSIOLOGY
影响因子：
--
作者：
KNIGHT, RT
通讯作者：
KNIGHT, RT
影响因子：
3
作者：
Iacono, WG;Malone, SM;McGue, M
通讯作者：
McGue, M
影响因子：
5.8
作者：
Ersche, Karen D.;Sahakian, Barbara J.
通讯作者：
Sahakian, Barbara J.