Preparation, characterization, and encapsulation/release studies of a composite nanofiber mat electrospun from an emulsion containing poly (lactic-co-glycolic acid).
Preparation, characterization, and encapsulation/release studies of a composite nanofiber mat electrospun from an emulsion containing poly (lactic-co-glycolic acid).
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DOI：
10.1016/j.polymer.2008.09.045
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发表时间：
2008-11-10
期刊：
影响因子：
4.6
通讯作者：
Fong, Hao
中科院分区：
文献类型：
--
作者：
Liao, Yiliang;Zhang, Lifeng;Gao, Yi;Zhu, Zheng-Tao;Fong, Hao
本研究的目的是研究静电纺复合纳米纤维垫的制备、表征和封装/释放性能。假设具有纳米级药物颗粒的复合纳米纤维垫浸渍在生物相容性和可生物降解的聚合物纳米纤维中，可以作为一种创新类型的组织工程支架，具有所需且可控的药物封装/释放特性。为了验证这一假设，我们制备并表征了由聚乳酸-乙醇酸共聚物 (PLGA) 罗丹明 B（模拟药物的模型化合物）、脱水山梨糖醇单油酸酯（Span-80，一种非离子乳化剂/表面活性剂，对细胞生长可能无毒/安全）、氯仿、DMF 和蒸馏水组成的乳液进行电纺的复合纳米纤维垫；记录并分析磷酸盐缓冲盐水 (pH = 7.4) 中罗丹明 B 的封装/释放曲线。为了进行比较，还制备了另外两种纳米纤维垫，由 (1) 含有 PLGA 和罗丹明 B 的溶液，以及 (2) 含有 PLGA、罗丹明 B 和 Span-80 的溶液电纺丝而成，并作为对照样品进行评估。结果表明，由乳液电纺而成的复合纳米纤维垫具有最理想且可控的罗丹明B包封/释放曲线以及优异的形态可持续性；因此，它可以用作药物封装/释放载体和组织工程支架。
The aim of this study was to investigate the preparation, characterization, and encapsulation/release performance of an electrospun composite nanofiber mat. The hypothesis was that the composite nanofiber mat with nano-scaled drug particles impregnated in biocompatible and biodegradable polymer nanofibers can serve as an innovative type of tissue engineering scaffold with desired and controllable drug encapsulation/release properties. To test the hypothesis, the composite nanofiber mat electrospun from an emulsion consisting of poly (lactic-co-glycolic acid) (PLGA) Rhodamine B (a model compound to simulate drugs), sorbitan monooleate (Span-80, a non-ionic emulsifier/surfactant that is presumably non-toxic/safe for cell-growth), chloroform, DMF, and distilled water was prepared and characterized; and the Rhodamine B encapsulation/release profile in phosphate buffered saline (pH = 7.4) was recorded and analyzed. For comparison purposes, two additional nanofiber mats electrospun from (1) a solution containing PLGA and Rhodamine B, and (2) a solution containing PLGA, Rhodamine B, and Span-80 were also prepared and assessed as the control samples. The results indicated that the composite nanofiber mat electrospun from the emulsion had the most desired and controllable Rhodamine B encapsulation/release profile and the excellent morphological sustainability; thus, it could be utilized as both a drug encapsulation/release vehicle and a tissue engineering scaffold.
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影响因子：
4.6
作者：
Fong, H;Chun, I;Reneker, DH
通讯作者：
Reneker, DH
影响因子：
4.5
作者：
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影响因子：
--
作者：
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影响因子：
3
作者：
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通讯作者：
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影响因子：
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作者：
Zhang, YZ;Wang, X;Ramakrishna, S
通讯作者：
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