Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns.
Development and morphogenesis of the Wolffian/epididymal duct, more twists and turns.
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DOI：
10.1016/j.ydbio.2008.10.012
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发表时间：
2009-01-01
影响因子：
2.7
通讯作者：
Hinton, Barry T.
中科院分区：
文献类型：
--
作者：
Joseph, Avenel;Yao, Humphrey;Hinton, Barry T.
关键词：
附睾在准备雄性生殖细胞受精方面发挥着关键作用。为了使附睾发挥这一作用，它必须在发育过程中经历一系列高度协调的分子和形态发生事件。这些事件始于沃尔夫管或肾管（男性生殖系统的胚胎前身）的形成，并以三维卷曲的出生后附睾结束，该附睾由几个独特的功能部分组成。风管如何从简单的直管转变为高度复杂的结构将是本文的重点。在回顾目前文献对附睾形态发生的理解时，我们将重点介绍一些经典的形态学研究，并讨论一些最近的遗传模型，这些模型都有助于我们对这个系统的理解。在公开信息稀缺的情况下，我们将提供值得进一步研究的潜在假设，并可能使用附睾作为管状形态发生的模型开辟新的探索方向。
The epididymis serves a critical function of preparing the male germ cells for fertilization. In order for the epididymis to carry out this role it must undergo a highly coordinated succession of molecular and morphogenic events during development. These events begin with the formation of the Wolffian or nephric duct, the embryonic precursor of the male reproductive system, and end with the three-dimensional coiled postnatal epididymis that is comprised of several distinctly functional segments. How the duct changes from a simple straight tube to a highly convoluted structure will be the focus of this article. In reviewing the literature's current understanding of epididymal morphogenesis, we will highlight some of the classic morphological studies and discuss some of the more recent genetic models that have all served to contribute to our understanding of this system. Where published information is scarce we will provide potential hypotheses that warrant further investigation and may open up new directions of exploration using the epididymis as a model for tubular morphogenesis.
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