Structure-property evaluation of thermally and chemically gelling injectable hydrogels for tissue engineering.
Structure-property evaluation of thermally and chemically gelling injectable hydrogels for tissue engineering.
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DOI：
10.1021/bm300797m
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发表时间：
2012-09-10
影响因子：
6.2
通讯作者：
Mikos, Antonios G.
中科院分区：
文献类型：
--
作者：
Ekenseair, Adam K.;Boere, Kristel W. M.;Tzouanas, Stephanie N.;Vo, Tiffany N.;Kasper, F. Kurtis;Mikos, Antonios G.
合成和溶液配方参数对一类新型的热和化学凝胶化水凝胶的溶胀和机械性能的影响进行了评价，该水凝胶结合了基于聚（N-异丙基丙烯酰胺）的含有环氧侧环的热凝胶化大分子单体与基于聚酰胺胺的亲水性和可降解的二胺交联大分子单体。通过网络亲水性和链重排能力的变化，解决了热凝胶化水凝胶发生显著脱水收缩的常见问题。所证明的在合成和配制阶段容易地调节形成后尺寸稳定性的能力代表了对利用聚（N-异丙基丙烯酰胺）基聚合物作为可注射生物材料的努力的显著的新贡献。此外，确定了相关条件下水凝胶系统的细胞相容性，同时证明了在高溶液渗透压摩尔浓度下的时间和剂量依赖性细胞毒性。这种可注射原位形成的可降解水凝胶具有可调的水含量，是许多组织工程应用的有希望的候选者，特别是用于细胞递送以促进非承重缺损中的快速组织再生。
The impact of synthesis and solution formulation parameters on the swelling and mechanical properties of a novel class of thermally and chemically gelling hydrogels combining poly(N-isopropylacrylamide)-based thermogelling macromers containing pendant epoxy rings with polyamidoamine-based hydrophilic and degradable diamine crosslinking macromers was evaluated. Through variation of network hydrophilicity and capacity for chain rearrangement, the often problematic tendency of thermogelling hydrogels to undergo significant syneresis was addressed. The demonstrated ability to easily tune post-formation dimensional stability at both the synthesis and formulation stages represents a significant novel contribution towards efforts to utilize poly(N-isopropylacrylamide)-based polymers as injectable biomaterials. Furthermore, the cytocompatibility of the hydrogel system under relevant conditions was established, while demonstrating time- and dose-dependent cytotoxicity at high solution osmolality. Such injectable in situ forming degradable hydrogels with tunable water content are promising candidates for many tissue engineering applications, particularly for cell delivery to promote rapid tissue regeneration in non-load-bearing defects.
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影响因子：
6.2
作者：
Kretlow, James D.;Hacker, Michael C.;Klouda, Leda;Ma, Brandy B.;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
DOI：
10.1081/ma-200050470
发表时间：
2005-03-01
期刊：
JOURNAL OF MACROMOLECULAR SCIENCE-PURE AND APPLIED CHEMISTRY
影响因子：
--
作者：
Dey, RK;Ray, AR
通讯作者：
Ray, AR
影响因子：
6.2
作者：
Robb, Stephanie A.;Lee, Bae Hoon;Vernon, Brent L.
通讯作者：
Vernon, Brent L.
影响因子：
6.2
作者：
Ekenseair, Adam K.;Boere, Kristel W. M.;Tzouanas, Stephanie N.;Vo, Tiffany N.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
3.6
作者：
Cui, Zhanwu;Lee, Bae Hoon;Vernon, Brent L.
通讯作者：
Vernon, Brent L.