Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women.
Determinants of plasma concentrations of perfluoroalkyl substances in pregnant Norwegian women.
复制标题
怀孕挪威妇女的全氟烷基物质血浆浓度的决定因素。
DOI：
10.1016/j.envint.2012.12.014
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发表时间：
2013-04
影响因子：
11.8
通讯作者：
Longnecker, M. P.
中科院分区：
文献类型：
--
作者：
Brantsaeter, A. L.;Whitworth, K. W.;Ydersbond, T. A.;Haug, L. S.;Haugen, M.;Knutsen, H. K.;Thomsen, C.;Meltzer, H. M.;Becher, G.;Sabaredzovic, A.;Hoppin, J. A.;Eggesbo, M.;Longnecker, M. P.
全氟烷基物质（PFASs）是一种广泛存在的污染物，与不利的健康影响有关，尽管不是一致的。饮食一直被认为是主要的接触源。本研究的目的是确定挪威孕妇血浆中四种PFASs的决定因素。这项研究基于挪威公共卫生研究所开展的挪威母亲和儿童队列研究（MoBa）。我们的样本包括2003-2004年间参加MoBa的487名女性。在妊娠17周完成一份关于社会人口、医疗和生殖史的问卷，在妊娠22周完成一份饮食问卷。母体血浆样本采集于妊娠17周左右。研究了四种全氟磺酸（全氟辛烷磺酸（PFOS）、全氟辛酸（PFOA）、全氟己烷磺酸（PFHxS）和全氟壬酸（PFNA））的血浆浓度与人口统计学、生活方式、饮食和妊娠相关协变量的关系。采用赤池信息准则（Akaike’s information criterion， AIC）优化多元线性回归模型，确定预测因子。胎次是对血浆PFAS浓度影响最大的决定因素，在简单回归模型中r2在0.09 ~ 0.32之间。在最佳多变量模型中，与未分娩妇女相比，已分娩妇女的PFOS、PFOA、PFHxS和PFNA浓度分别降低46%、70%、19%和62% （p<0.001， PFHxS除外，p<0.01）。在所有这些模型中，母乳喂养持续时间与PFAS水平降低有关。PFOA显示母乳喂养减少最多，在典型情况下每月母乳喂养减少2-3%。自最近怀孕以来，全氟辛烷磺酸、全氟辛酸和全氟辛酸的水平随着时间的推移而增加。虽然怀孕相关因素是最重要的预测因素，但饮食是一个重要因素，可以解释高达4%的差异。估计膳食PFAS摄入量增加四分之一与血浆PFOS、PFOA、PFHxS和PFNA浓度分别增加7.2%、3.3%、5.8%和9.8%相关，导致PFAS浓度的绝对变化很小，但并非微不足道。妊娠史和母乳喂养史是该孕妇样本中PFASs最重要的决定因素。
Perfluoroalkyl substances (PFASs) are widespread pollutants that have been associated with adverse health effects although not on a consistent basis. Diet has been considered the main source of exposure. The aim of the present study was to identify determinants of four plasma PFASs in pregnant Norwegian women. This study is based in the Norwegian Mother and Child Cohort Study (MoBa) conducted by the Norwegian Institute of Public Health. Our sample included 487 women who enrolled in MoBa from 2003–2004. A questionnaire regarding sociodemographic, medical, and reproductive history was completed at 17 weeks gestation and a dietary questionnaire was completed at 22 weeks gestation. Maternal plasma samples were obtained around 17 weeks of gestation. Plasma concentrations of four PFASs (perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), perfluorohexane sulfonate (PFHxS), and perfluorononanoate (PFNA)) were examined in relation to demographic, lifestyle, dietary, and pregnancy-related covariates. Predictors were identified by optimizing multiple linear regression models using Akaike’s information criterion (AIC). Parity was the determinant with the largest influence on plasma PFAS concentrations, with r2 between 0.09 and 0.32 in simple regression models. In optimal multivariate models, when compared to nulliparous women, parous women had 46%, 70%, 19%, and 62% lower concentrations of PFOS, PFOA, PFHxS, and PFNA respectively (p<0.001 except for PFHxS, p<0.01). In all these models, duration of breastfeeding was associated with reduced PFAS levels. PFOA showed the largest reduction from breastfeeding, with a 2–3% reduction per month of breastfeeding in typical cases. Levels of PFOS, PFOA, and PFNA increased with time since most recent pregnancy. While pregnancy-related factors were the most important predictors, diet was a significant factor explaining up to 4% of the variance. One quartile increase in estimated dietary PFAS intake was associated with plasma PFOS, PFOA, PFHxS, and PFNA concentration increases of 7.2%, 3.3%, 5.8% and 9.8%, respectively, resulting in small, although non-trivial absolute changes in PFAS concentrations. The history of previous pregnancies and breastfeeding were the most important determinants of PFASs in this sample of pregnant women.
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影响因子：
11.4
作者：
Haug, Line S.;Thomsen, Cathrine;Bechert, Georg
通讯作者：
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通讯作者：
Volkel, Wolfgang