Aberrant parietal cortex developmental trajectories in girls with Turner syndrome and related visual-spatial cognitive development: a preliminary study.
Aberrant parietal cortex developmental trajectories in girls with Turner syndrome and related visual-spatial cognitive development: a preliminary study.
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DOI：
10.1002/ajmg.b.32256
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发表时间：
2014-09
影响因子：
2.8
通讯作者：
Reiss, Allan L.
中科院分区：
文献类型：
--
作者：
Green, Tamar;Chromik, Lindsay C.;Mazaika, Paul K.;Fierro, Kyle;Raman, Mira M.;Lazzeroni, Laura C.;Hong, David S.;Reiss, Allan L.
特纳综合征（TS）是由女性X染色体的部分或完全缺失引起的。患有TS的女孩表现出视觉空间技能的缺陷，以及支持这些认知功能的顶叶皮层的脑容量和表面积减少。因此，测量顶叶皮层的发展轨迹和相关的视觉空间认知在TS可能提供新的见解关键的大脑行为协会。在这项纵向研究中，我们获得了结构MRI数据，并评估了16名（年龄：8.23 ±2.5）TS女孩和13名年龄匹配的对照组在两个时间点的视觉空间技能。根据双侧顶叶皮质的表面分割计算灰、白色物质体积、表面积和皮质厚度，并使用NEPSY Arrows子测试评估视觉空间能力。体积和认知标量进行建模，以获得年龄相关的变化估计。结果显示TS女孩在儿童期左侧上级顶叶区域的白色物质体积（P =0.011，校正）和表面积（P =0.036，校正）异常生长。其他顶叶子区域显着较小的TS女孩在这两个时间点，但没有显示出不同的增长轨迹相对于对照组。此外，我们发现，视觉空间技能表现出扩大赤字TS女孩相对于对照组（P =0.003）。年轻女孩与TS表现出异常的轨迹顶叶皮层和认知发展在童年时期。阐明这一人群的异常神经发育轨迹对于确定大脑成熟的特定阶段至关重要，这些阶段特别依赖于TS相关的遗传和激素因素。
Turner syndrome (TS) arises from partial or complete absence of the X-chromosome in females. Girls with TS show deficits in visual–spatial skills as well as reduced brain volume and surface area in the parietal cortex which supports these cognitive functions. Thus, measuring the developmental trajectory of the parietal cortex and the associated visual–spatial cognition in TS may provide novel insights into critical brain-behavior associations. In this longitudinal study, we acquired structural MRI data and assessed visual–spatial skills in 16 (age: 8.23 ±2.5) girls with TS and 13 age-matched controls over two time-points. Gray and white matter volume, surface area and cortical thickness were calculated from surfaced based segmentation of bilateral parietal cortices, and the NEPSY Arrows subtest was used to assess visual–spatial ability. Volumetric and cognitive scalars were modeled to obtain estimates of age-related change. The results show aberrant growth of white matter volume (P =0.011, corrected) and surface area (P =0.036, corrected) of the left superior parietal regions during childhood in girls with TS. Other parietal sub-regions were significantly smaller in girls with TS at both time-points but did not show different growth trajectories relative to controls. Furthermore, we found that visual–spatial skills showed a widening deficit for girls with TS relative to controls (P =0.003). Young girls with TS demonstrate an aberrant trajectory of parietal cortical and cognitive development during childhood. Elucidating aberrant neurodevelopmental trajectories in this population is critical for determining specific stages of brain maturation that are particularly dependent on TS-related genetic and hormonal factor.
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影响因子：
16.2
作者：
Giedd, Jay N.;Rapoport, Judith L.
通讯作者：
Rapoport, Judith L.
影响因子：
3.7
作者：
Bray, Signe;Dunkin, Bria;Reiss, Allan L.
通讯作者：
Reiss, Allan L.
影响因子：
3.7
作者：
Kesler, Shelli R.;Menon, Vinod;Reiss, Allan L.
通讯作者：
Reiss, Allan L.
影响因子：
--
作者：
Hong, David;Kent, Jamie Scaletta;Kesler, Shelli
通讯作者：
Kesler, Shelli
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y