Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.
Diffusion MRI-guided theta burst stimulation enhances memory and functional connectivity along the inferior longitudinal fasciculus in mild cognitive impairment.
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DOI：
10.1073/pnas.2113778119
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发表时间：
2022-05-24
影响因子：
11.1
通讯作者：
中科院分区：
文献类型：
--
作者：
脑白色物质纤维束描记术引导的无创性Theta爆发刺激（TBS）是一种有前途的方法，可以加强轻度认知障碍患者海马的静息状态功能连接，提高联想记忆表现。通过这种方法，我们的研究结果增加了对TBS如何从浅表刺激部位沿着下纵束沿着传播到海马的了解。这项研究的结果提供了一个创新的平台，开发一个非侵入性海马刺激协议，有很大的潜力，在增强轻度认知障碍的记忆功能。衰老过程中的轻度认知障碍（MCI）通常是阿尔茨海默病的先兆，因此，在MCI症状变得医学难治之前进行早期干预以保护认知能力是特别重要的。功能性MRI引导的经颅磁刺激是一种很有前途的方法，用于调节健康成年人海马功能连接和增强记忆。在这里，我们将这些先前的研究结果扩展到MCI患者，并利用θ脉冲群刺激（TBS）和来自扩散加权MRI的白色物质纤维束成像来靶向海马。我们的初步研究结果表明，TBS可用于改善MCI患者的联想记忆性能，并增加海马和其他脑区的静息态功能连接，包括枕梭状回、额眶皮质、壳核、海马旁后回和颞极，沿着下纵束。虽然样本量很小，但这些结果揭示了TBS如何从顶叶周围的表层皮层传播到海马。
Noninvasive theta burst stimulation (TBS) guided by brain white matter tractography is a promising approach to strengthen resting-state functional connectivity of the hippocampus and increase associative memory performance in individuals with mild cognitive impairment. With this approach, our findings add insight into how TBS propagates from the superficial stimulation site to the hippocampus along the inferior longitudinal fasciculus. Results of this study provide an innovative platform for developing a noninvasive hippocampal stimulation protocol that has great potential in enhancing memory function in mild cognitive impairment. Mild cognitive impairment (MCI) during aging is often a harbinger of Alzheimer’s disease, and, therefore, early intervention to preserve cognitive abilities before the MCI symptoms become medically refractory is particularly critical. Functional MRI–guided transcranial magnetic stimulation is a promising approach for modulating hippocampal functional connectivity and enhancing memory in healthy adults. Here, we extend these previous findings to individuals with MCI and leverage theta burst stimulation (TBS) and white matter tractography derived from diffusion-weighted MRI to target the hippocampus. Our preliminary findings suggested that TBS could be used to improve associative memory performance and increase resting-state functional connectivity of the hippocampus and other brain regions, including the occipital fusiform, frontal orbital cortex, putamen, posterior parahippocampal gyrus, and temporal pole, along the inferior longitudinal fasciculus in MCI. Although the sample size is small, these results shed light on how TBS propagates from the superficial cortex around the parietal lobe to the hippocampus.
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影响因子：
6.8
作者：
De Risio L;Borgi M;Pettorruso M;Miuli A;Ottomana AM;Sociali A;Martinotti G;Nicolò G;Macrì S;di Giannantonio M;Zoratto F
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DOI：
10.3988/jcn.2018.14.2.158
发表时间：
2018-04
期刊：
Journal of clinical neurology (Seoul, Korea)
影响因子：
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作者：
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通讯作者：
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影响因子：
2
作者：
Chen, Janice;Olsen, Rosanna K.;Wagner, Anthony D.
通讯作者：
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影响因子：
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作者：
Goyal, Abhinav;Miller, Jonathan;Jacobs, Joshua
通讯作者：
Jacobs, Joshua
DOI：
10.1073/pnas.1806165115
发表时间：
2018-11-20
影响因子：
11.1
作者：
Barat, Elodie;Wirth, Sylvia;Duhamel, Jean-Rene
通讯作者：
Duhamel, Jean-Rene