Glucose Hypometabolism in Hippocampal Subdivisions in Alzheimer's Disease: A Pilot Study Using High-Resolution ¹⁸F-FDG PET and 7.0-T MRI.
Glucose Hypometabolism in Hippocampal Subdivisions in Alzheimer's Disease: A Pilot Study Using High-Resolution ¹⁸F-FDG PET and 7.0-T MRI.
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DOI：
10.3988/jcn.2018.14.2.158
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发表时间：
2018-04
期刊：
影响因子：
--
通讯作者：
Park KH
中科院分区：
文献类型：
--
作者：
Choi EJ;Son YD;Noh Y;Lee H;Kim YB;Park KH
海马萎缩是阿尔茨海默病（AD）的重要临床诊断标志，因此海马活动及其亚区的评估可能提供宝贵的信息。本研究比较了轻度AD患者和健康对照者海马亚区的葡萄糖代谢。高分辨率T2* 加权梯度回波磁共振成像（MRI）图像和18F-氟脱氧葡萄糖（FDG）正电子发射断层扫描（PET）图像分别使用7.0-T MRI和高分辨率研究断层扫描FDG-PET，在9个早期AD患者和10个健康受试者。海马体分为三个相等的部分（前，中，后），并在每个部分的感兴趣的区域（ROI）被绘制在角氨（CA）1，CA 2/3，CA 4/齿状回（DG），和下托。计算每个ROI海马分区的标准化摄取值，作为相对于脑桥标准化摄取值的比率。使用Mann-Whitney U检验进行统计分析。与健康对照组相比，早期AD患者的代谢活动显著减少，（p=0.050）和后（p=0.034）右侧海马CA 2/3区，整个左侧海马体前部CA 2/3区的活动显著减少（p=0.027）和CA 4/DG（p=0.027）区域、中间CA 1区域（p=0.011）和后部CA 1（p=0.034）、CA 2/3（p=0.007）和CA 4/DG（p=0.014）区域。使用高分辨率PET-MRI融合图像来识别海马分区并评估子区域中的葡萄糖代谢是可能的。在早期AD患者中，代谢活性的降低沿着海马轴变化。
Atrophy of the hippocampus is an important clinical diagnostic marker of Alzheimer's disease (AD), and so assessments of hippocampal activity and its subdivisions might provide invaluable information. This study compared the glucose metabolism of hippocampal subdivisions in mild-AD patients and healthy controls. High-resolution T2*-weighted gradient-echo magnetic resonance imaging (MRI) images and 18F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) images were acquired using 7.0-T MRI and high-resolution research tomograph FDG-PET, respectively, in 9 early-stage AD patients and 10 healthy subjects. The hippocampal body was divided into three equal parts (anterior, middle, and posterior), and in each part a region of interest (ROI) was drawn over the cornus ammonis (CA)1, CA2/3, CA4/dentate gyrus (DG), and subiculum. The standardized uptake values of the hippocampal subdivisions were calculated for each ROI as ratios relative to the pons standardized uptake value. Statistical analysis was conducted using the Mann-Whitney U test. Patients with early-stage AD patients showed significantly less metabolic activity than healthy controls focally in the middle (p=0.050) and posterior (p=0.034) CA2/3 regions of the right hippocampus, and significantly less activity throughout the left hippocampal body in the anterior CA2/3 (p=0.027) and CA4/DG (p=0.027) regions, the middle CA1 region (p=0.011), and the posterior CA1 (p=0.034), CA2/3 (p=0.007), and CA4/DG (p=0.014) regions. It was possible to use high-resolution PET-MRI fusion images to identify hippocampus subdivisions and assess glucose metabolism in the subfields. Reductions in metabolic activity were found to vary along the hippocampal axis in early-stage AD patients.
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