Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
Effects of vitamin D supplementation on cognitive and emotional functioning in young adults--a randomised controlled trial.
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DOI：
10.1371/journal.pone.0025966
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发表时间：
2011
期刊：
影响因子：
3.7
通讯作者：
McGrath JJ
中科院分区：
文献类型：
--
作者：
Dean AJ;Bellgrove MA;Hall T;Phan WM;Eyles DW;Kvaskoff D;McGrath JJ
流行病学研究将维生素D状态与各种大脑相关结果联系起来。然而，很少有试验研究补充剂是否可以改善这些结果，也没有研究对认知的影响。这项研究检查了维生素D补充剂是否会改善认知和情绪功能的各种指标，并假设与安慰剂相比，补充剂会改善这些结果。健康的年轻人被招募到昆士兰州大学进行的平行臂双盲试验中。参与者被随机分配接受维生素D（每天一粒胶囊，含有5000 IU胆钙化醇）或相同的安慰剂胶囊，持续6周。所有参与者和结局评估者均对组分配不知情。在基线和6周时评估的主要结局指标是工作记忆、反应抑制和认知灵活性。次要结果是：幻觉倾向，精神病样经历，抑郁，焦虑和愤怒的评级。招募了128名参与者，随机分配并纳入主要分析（维生素D n = 63;安慰剂n = 65）。 尽管活动组的维生素D状态显著增加，但在工作记忆（F = 1.09; p = 0.30）、反应抑制（F = 0.82; p = 0.37）、认知灵活性（F = 1.37; p = 0.24）或次要结局方面未观察到显著变化。 未报告严重不良反应。我们的研究结果表明，维生素D补充剂不会影响健康年轻人的认知或情感功能。未来需要在目标人群中进行对照试验，以确定补充剂是否可以改善这些领域的功能。澳大利亚和新西兰临床试验注册中心; ACTRN 12610000318088。
Epidemiological research links vitamin D status to various brain-related outcomes. However, few trials examine whether supplementation can improve such outcomes and none have examined effects on cognition. This study examined whether Vitamin D supplementation led to improvements in diverse measures of cognitive and emotional functioning, and hypothesised that supplementation would lead to improvements in these outcomes compared to placebo. Healthy young adults were recruited to a parallel-arm, double-blind trial conducted at The University of Queensland. Participants were randomly allocated to receive Vitamin D (one capsule daily, containing 5000 IU cholecalciferol) or identical placebo capsule for six weeks. All participants and outcome assessors were blinded to group assignment. Primary outcome measures assessed at baseline and 6 weeks were working memory, response inhibition and cognitive flexibility. Secondary outcomes were: hallucination-proneness, psychotic-like experiences, and ratings of depression, anxiety and anger. 128 participants were recruited, randomised and included in primary analyses (vitamin D n = 63; placebo n = 65). Despite significant increases in vitamin D status in the active group, no significant changes were observed in working memory (F = 1.09; p = 0.30), response inhibition (F = 0.82; p = 0.37), cognitive flexibility (F = 1.37; p = 0.24) or secondary outcomes. No serious adverse effects were reported. Our findings indicate that vitamin D supplementation does not influence cognitive or emotional functioning in healthy young adults. Future controlled trials in targeted populations of interest are required to determine whether supplementation can improve functioning in these domains. Australian and New Zealand Clinical Trials Registry; ACTRN12610000318088.
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影响因子：
9.9
作者：
Buell, J. S.;Dawson-Hughes, B.;Tucker, K. L.
通讯作者：
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影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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通讯作者：
Eyles, Darryl W.
影响因子：
3.7
作者：
Eyles, D W;Feron, F;Burne, T H J
通讯作者：
Burne, T H J