Complex virome in feces from Amerindian children in isolated Amazonian villages.
Complex virome in feces from Amerindian children in isolated Amazonian villages.
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DOI：
10.1038/s41467-018-06502-9
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发表时间：
2018-10-15
影响因子：
16.6
通讯作者：
Delwart E
中科院分区：
文献类型：
--
作者：
Siqueira JD;Dominguez-Bello MG;Contreras M;Lander O;Caballero-Arias H;Xutao D;Noya-Alarcon O;Delwart E
在小的孤立人群中传播的病毒数量可能会通过病毒预防和罕见的引入而减少。在这里，我们使用病毒宏基因组学来表征来自大城市中心和三个与外界接触最少的美洲印第安人村庄的健康儿童粪便中的真核病毒组。从每个位点对主要来自小核糖核酸病毒科和杯状病毒科的许多人肠道病毒进行测序。来自同一村庄的多名儿童传播密切相关的病毒，反映了频繁的传播集群。与世隔绝的村民的粪便中还含有来自小核糖核酸病毒目和CRESS-DNA组的多种未知细胞来源的病毒基因组，以及更高水平的线虫和原生动物DNA。尽管文化和地理上的隔离，人类肠道病毒的多样性因此没有减少这些亚马逊村庄。频繁的病毒引入和/或增加肠道感染的易感性可能是导致孤立村庄中美洲印第安儿童粪便病毒组复杂的原因。作者比较了来自亚马逊雨林三个孤立村庄的人类粪便病毒组和来自城市居民的病毒组。他们报告说，在孤立的村庄，人类病毒的多样性并没有减少，这表明病毒频繁引入或对肠道感染的易感性增加。
The number of viruses circulating in small isolated human populations may be reduced by viral extinctions and rare introductions. Here we used viral metagenomics to characterize the eukaryotic virome in feces from healthy children from a large urban center and from three Amerindian villages with minimal outside contact. Numerous human enteric viruses, mainly from the Picornaviridae and Caliciviridae families, were sequenced from each of the sites. Multiple children from the same villages shed closely related viruses reflecting frequent transmission clusters. Feces of isolated villagers also contained multiple viral genomes of unknown cellular origin from the Picornavirales order and CRESS-DNA group and higher levels of nematode and protozoan DNA. Despite cultural and geographic isolation, the diversity of enteric human viruses was therefore not reduced in these Amazonian villages. Frequent viral introductions and/or increased susceptibility to enteric infections may account for the complex fecal virome of Amerindian children in isolated villages. The authors compare human fecal viromes from three isolated villages of the Amazon rain forest with those from city dwellers. They report that the diversity of human viruses is not reduced in isolated villages, suggesting frequent viral introductions or increased susceptibility to enteric infections.
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影响因子：
5.4
作者：
Farkas, Tibor;Sestak, Karol;Jiang, Xi
通讯作者：
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作者：
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通讯作者：
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