Extent With Modification: Leg Patterning in the Beetle Tribolium castaneum and the Evolution of Serial Homologs.
Extent With Modification: Leg Patterning in the Beetle Tribolium castaneum and the Evolution of Serial Homologs.
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DOI：
10.1534/g3.111.001537
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发表时间：
2012-02
期刊：
影响因子：
--
通讯作者：
Jockusch EL
中科院分区：
文献类型：
--
作者：
Angelini DR;Smith FW;Jockusch EL
序列同系物是在身体计划中不同位置发展的相似结构。这些结构共享发育模式的某些方面，但不是全部，它们的进化被认为受到共享的、多效性基因功能的限制。本文描述了赤粉甲腿部发育过程中17个发育基因的功能。本研究提供了黑腹果蝇和卡氏果蝇附肢发育的信息比较，以及卡氏果蝇胚胎和成体发育的比较，以及一系列同源附肢发育的比较。腿间隙基因Distal-less和Dachshund在功能上是保守的。Notch信号、与ODD-SKIP相关的锌指转录因子和BRAC在促进关节发育方面具有保守的功能。同胸击倒改变了腿部近端节段的特性，但不会减少生长。LIM1对于中间腿的发育是必需的，但不是像黑腹鱼那样的远足踝和足前肌的发育。踝关节的发育需要十足的瘫痪、圆润、无刺、突然和无脊椎动物，以及由Keren编码的EGF配体。卡氏毛滴虫的后胸腿有四个脚踝，而其他腿有五个。颧骨的基因活动模式表明，导致节段数量差异的原因是颧骨区域中部的模式，而不是近端或最远端区域的模式。通过与最近对卡氏木霉附属物发育的其他研究进行比较，我们检验了系列同源基因进化过程中发育的模块化或相互依赖的假说。
Serial homologs are similar structures that develop at different positions within a body plan. These structures share some, but not all, aspects of developmental patterning, and their evolution is thought to be constrained by shared, pleiotropic gene functions. Here we describe the functions of 17 developmental genes during metamorphic development of the legs in the red flour beetle, Tribolium castaneum. This study provides informative comparisons between appendage development in Drosophila melanogaster and T. castaneum, between embryonic and adult development in T. castaneum, and between the development of serially homologous appendages. The leg gap genes Distal-less and dachshund are conserved in function. Notch signaling, the zinc-finger transcription factors related to odd-skipped, and bric-à-brac have conserved functions in promoting joint development. homothorax knockdown alters the identity of proximal leg segments but does not reduce growth. Lim1 is required for intermediate leg development but not distal tarsus and pretarsus development as in D. melanogaster. Development of the tarsus requires decapentaplegic, rotund, spineless, abrupt, and bric-à-brac and the EGF ligand encoded by Keren. Metathoracic legs of T. castaneum have four tarsomeres, whereas other legs have five. Patterns of gene activity in the tarsus suggest that patterning in the middle of the tarsal region, not the proximal- or distal-most areas, is responsible for this difference in segment number. Through comparisons with other recent studies of T. castaneum appendage development, we test hypotheses for the modularity or interdependence of development during evolution of serial homologs.
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DOI：
10.1007/bf02438941
发表时间：
1989-01-01
期刊：
ROUXS ARCHIVES OF DEVELOPMENTAL BIOLOGY
影响因子：
--
作者：
COHEN, SM;JURGENS, G
通讯作者：
JURGENS, G
影响因子：
2.7
作者：
Angelini, David R.;Kikuchi, Moto;Jockusch, Elizabeth L.
通讯作者：
Jockusch, Elizabeth L.
影响因子：
2.7
作者：
Abzhanov, A;Kaufman, TC
通讯作者：
Kaufman, TC
影响因子：
64.8
作者：
Engel, MS;Grimaldi, DA
通讯作者：
Grimaldi, DA
影响因子：
64.8
作者：
Campbell, G
通讯作者：
Campbell, G