Spontaneous neural activity in the primary visual cortex of retinal degenerated rats
Spontaneous neural activity in the primary visual cortex of retinal degenerated rats
复制标题
视网膜退化大鼠初级视觉皮层的自发神经活动
DOI：
10.1016/j.neulet.2016.04.062
复制
发表时间：
2016-06
影响因子：
2.5
通讯作者：
Leanne Lai Hang Chan
中科院分区：
文献类型：
--
作者：
Chen Ke;Xu Ping;Tsz Kin Ng;Leanne Lai Hang Chan
视网膜变性（Retinal degeneration，RD）模型长期以来被广泛应用于视网膜变性疾病的研究。视网膜变性过程中的变化的生物学和电生理学表现已经得到了很好的研究，因此，本研究的目的是研究RD在初级视皮层的电生理效应。我们在细胞外记录了RD大鼠初级视皮层的自发神经活动。随后分析了自发神经活动的放电频率、峰间期（ISI）和Lempel-Ziv（LZ）复杂度。与对照组相比，发现RD模型的初级视皮层神经元放电更频繁。此外，在RD模型中，自发神经放电的LZ复杂性降低。这些结果提示RD的进展不仅影响视网膜本身，而且还影响初级视皮层，导致抑制-兴奋系统失衡以及新的自发活动模式出现率降低。
Retinal degeneration (RD) models have been widely used to study retinal degenerative diseases for a long time. The biological and electrophysiological presentations of changes in the retina during degeneration progress have been well investigated; thus, the present study is aimed at investigating the electrophysiological effects of RD in the primary visual cortex. We extracellularly recorded the spontaneous neural activities in the primary visual cortex of RD rats. The firing rate, interspike interval (ISI) and Lempel-Ziv (LZ) complexity of spontaneous neural activities were subsequently analyzed. When compared to the control group, it was found that the neurons in primary visual cortex of the RD model fired more frequently. In addition, there was a decrease in LZ complexity of spontaneous neural firing in the RD model. These results suggest that the progress of RD may not only affect the retina itself but also the primary visual cortex, which may result in an unbalanced inhibition-excitation system as well as the decreased arising rate of new patterns of spontaneous activities.
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DOI：
10.1016/j.pnpbp.2013.01.018
发表时间：
2013-08
影响因子：
5.6
作者：
A. Yang;S. Tsai
通讯作者：
A. Yang;S. Tsai
DOI：
10.17077/etd.ipizeeoq
发表时间：
2010
期刊：
--
影响因子：
--
作者：
E. Nylen
通讯作者：
E. Nylen
DOI：
10.1111/ejn.12349
发表时间：
2013-11
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Shao Y;Keliris GA;Papanikolaou A;Fischer MD;Zobor D;Jägle H;Logothetis NK;Smirnakis SM
通讯作者：
Smirnakis SM
DOI：
10.1109/iembs.2005.1615472
发表时间：
2005
期刊：
2005 IEEE Engineering in Medicine and Biology 27th Annual Conference
影响因子：
--
作者：
Carlos Gómez;R. Hornero;D. Abásolo;M. López;Alberto Fernández
通讯作者：
Carlos Gómez;R. Hornero;D. Abásolo;M. López;Alberto Fernández
影响因子：
1.8
作者：
Gias, Carlos;Vugler, Anthony;Coffey, Peter J.
通讯作者：
Coffey, Peter J.