Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children.
Interrelation between homocysteine metabolism and the development of autism spectrum disorder in children.
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同型半胱氨酸代谢与儿童自闭症谱系障碍发展之间的相互关系
DOI：
10.3389/fnmol.2022.947513
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发表时间：
2022
影响因子：
4.8
通讯作者：
Zhu, Changlian
中科院分区：
文献类型：
--
作者：
Li, Bingbing;Xu, Yiran;Pang, Dizhou;Zhao, Qiang;Zhang, Lingling;Li, Ming;Li, Wenhua;Duan, Guiqin;Zhu, Changlian
有证据表明，同型半胱氨酸（叶酸和维生素B12代谢的重要中间体）的循环浓度失调与自闭症谱系障碍（ASD）有关，但尚未报道全面的评估及其与疾病特征的相关性。多变量有序回归和限制性三次样条（RCS）模型被用来估计血清同型半胱氨酸，叶酸，维生素B12水平和ASD儿童的临床结果和严重程度之间的独立相关性。校正混杂因素后，ASD患儿血清同型半胱氨酸水平显著高于健康对照组（β：0.370，95% CI：0.299~0.441，p < 0.001）。此外，同型半胱氨酸对区分ASD儿童和健康受试者具有良好的诊断能力（AUC：0.899，p < 0.001）。RCS模型表明血清同型半胱氨酸与ASD风险之间存在正相关和线性相关。叶酸水平最低四分位数与ASD严重程度呈正相关（OR：4.227，95% CI：1.022~17.488，p = 0.041），血清叶酸水平与ASD严重程度呈线性负相关。此外，叶酸和维生素B12浓度的降低与Gesell发育表中适应行为发育不良有关（p < 0.05）。总体而言，高半胱氨酸水平升高与ASD呈线性相关，因此是ASD的一种新型诊断生物标志物。叶酸和维生素B12浓度的降低与ASD儿童的临床表现较差相关。这些发现表明，降低同型半胱氨酸的干预措施或叶酸和维生素B12补充剂可能是ASD的可行治疗策略。
Evidence is emerging that dysregulation of circulating concentrations of homocysteine, an important intermediate in folate and vitamin B12 metabolism, is associated with autism spectrum disorder (ASD), but comprehensive assessments and correlations with disease characteristics have not been reported. Multivariate ordinal regression and restricted cubic spline (RCS) models were used to estimate independent correlations between serum homocysteine, folate, and vitamin B12 levels and clinical outcomes and severity of children with ASD. After adjusting for confounding factors, serum homocysteine levels were significantly higher in children with ASD than in healthy controls (β: 0.370; 95% CI: 0.299~0.441, p < 0.001). Moreover, homocysteine had a good diagnostic ability for distinguishing children with ASD from healthy subjects (AUC: 0.899, p < 0.001). The RCS model indicated a positive and linear association between serum homocysteine and the risk of ASD. The lowest quartile of folate was positively associated with ASD severity (OR: 4.227, 95% CI: 1.022~17.488, p = 0.041) compared to the highest quartile, and serum folate showed a negative and linear association with ASD severity. In addition, decreased concentrations of folate and vitamin B12 were associated with poor adaptive behavior developmental quotients of the Gesell Developmental Schedules (p < 0.05). Overall, an increased homocysteine level was associated with ASD in a linear manner and is thus a novel diagnostic biomarker for ASD. Decreased concentrations of folate and vitamin B12 were associated with poor clinical profiles of children with ASD. These findings suggest that homocysteine-lowering interventions or folate and vitamin B12 supplementation might be a viable treatment strategy for ASD.
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DOI：
10.9758/cpn.2018.16.4.383
发表时间：
2018-11-30
期刊：
Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology
影响因子：
--
作者：
Altun H;Kurutaş EB;Şahin N;Güngör O;Fındıklı E
通讯作者：
Fındıklı E
影响因子：
7.1
作者：
James, S. Jill;Melnyk, Stepan;Gaylor, David W.
通讯作者：
Gaylor, David W.
影响因子：
--
作者：
Bobrowski-Khoury N;Ramaekers VT;Sequeira JM;Quadros EV
通讯作者：
Quadros EV
影响因子：
--
作者：
Frye RE;Melnyk S;Fuchs G;Reid T;Jernigan S;Pavliv O;Hubanks A;Gaylor DW;Walters L;James SJ
通讯作者：
James SJ
影响因子：
4.8
作者：
Hope, Sigrun;Naerland, Terje;Andreassen, Ole A.
通讯作者：
Andreassen, Ole A.