Alcohol Drinking and Blood Alcohol Concentration Revisited.
Alcohol Drinking and Blood Alcohol Concentration Revisited.
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饮酒和血液酒精浓度重新审视。
DOI：
10.1111/acer.13549
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发表时间：
2018-03
期刊：
影响因子：
--
通讯作者：
Froehlich JC
中科院分区：
文献类型：
--
作者：
Dilley JE;Nicholson ER;Fischer SM;Zimmer R;Froehlich JC
人们普遍认为，血液中的酒精含量反映了饮酒量。然而，除了饮酒量之外，还有几个因素会影响血液酒精浓度（BAC）。目前的研究探讨了酒精剂量，浓度和体积对高酒精饮用（HAD）表型大鼠BAC的影响。第一项研究调查了饮酒量与BAC之间的关系。对未接触过酒精的雄性HAD大鼠（N=7）连续9天给予酒精，每天2小时，随意进食和饮水。酒精摄入量和BAC在30，60和90分钟后开始访问。研究二检查了改变酒精剂量、浓度和体积对BAC的影响（通过曲线下面积测量）。通过胃内插管向未经酒精处理的雄性HAD大鼠（N=39）输注1.16、2.44或3.38 g酒精/kg BW，通过改变酒精体积同时保持浓度恒定或通过保持体积恒定同时改变浓度来产生。其他大鼠输注10%、15%或20%v/v酒精溶液，同时保持剂量恒定。BAC与酒精摄入量（g/kg BW）与总液体摄入量（ml）的比值（R=0.85-0.97，p<0.05-p<0.001）的相关性比与酒精摄入量（g/kg BW）（R=0.70-0.81，p<0.05）的相关性更强。在酒精输注开始后的第一个小时内，无论是否通过改变酒精体积或浓度来达到剂量，都没有观察到酒精剂量的影响。一小时后，较高的酒精剂量预示着较高的BAC。事实上，在摄入酒精后的前30分钟内，酒精剂量的三倍差异并没有导致BAC的显著差异，这对解释在这段时间内测量酒精敏感终点的研究具有潜在的重要意义。
It is widely assumed that the amount of alcohol in the blood reflects the amount of alcohol consumed. However, several factors in addition to amount of alcohol consumed can influence blood alcohol concentration (BAC). The current study examines the effect of alcohol dose, concentration, and volume on BAC in rats with a high alcohol drinking (HAD) phenotype. Study one examined the relationship between the amount of alcohol consumed and BAC. Alcohol-naïve, male, HAD rats (N=7) were given access to alcohol for 2 hrs/day for 9 consecutive days with food and water ad libitum. Alcohol intake and BAC were measured at 30, 60, and 90 minutes after onset of access. Study two examined the effects of altering alcohol dose, concentration, and volume on BAC (as measured by area under the curve). Alcohol-naïve, male, HAD rats (N=39) were infused, via an intragastric cannulus, with 1.16, 2.44, or 3.38 g alcohol/kg BW, produced by varying alcohol volume while holding concentration constant or by holding volume constant while varying concentration. Other rats were infused with 10%, 15%, or 20% v/v alcohol solutions while holding dose constant. BAC was more strongly correlated with the ratio of alcohol intake (g/kg BW) to total fluid intake (mls) (R=0.85–0.97, p<0.05–p<0.001) than it was with the amount of alcohol consumed (g/kg BW) (R=0.70–0.81, p<0.05). No effect of alcohol dose was seen during the first hour following the onset of an alcohol infusion regardless of whether dose was achieved by altering alcohol volume or concentration. After one hour, higher alcohol doses were predictive of greater BACs. The fact that a three-fold differences in alcohol dose did not result in significant differences in BACs during the first 30 minutes after ingestion of alcohol has potentially important implications for interpretation of studies that measure alcohol sensitive endpoints during this time.
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影响因子：
3.8
作者：
BOROWITZ, JL;MOORE, PF;MIYA, TS
通讯作者：
MIYA, TS
影响因子：
2.3
作者：
Grahame, NJ;Grose, AM
通讯作者：
Grose, AM
影响因子：
10.6
作者：
Gomez, Rosane;Behar, Kevin L.;Watzl, June;Weinzimer, Stuart A.;Gulanski, Barbara;Sanacora, Gerard;Koretski, Julia;Guidone, Elizabeth;Jiang, Lihong;Petrakis, Ismene L.;Pittman, Brian;Krystal, John H.;Mason, Graeme F.
通讯作者：
Mason, Graeme F.
DOI：
10.1111/j.1530-0277.1999.tb04131.x
发表时间：
1999-03-01
影响因子：
3.2
作者：
Crippens, D;White, ML;Gonzales, RA
通讯作者：
Gonzales, RA
影响因子：
3.1
作者：
AURES, D;GUTH, PH;GROSSMAN, MI
通讯作者：
GROSSMAN, MI