Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults.
Early-life and contemporaneous nutritional and environmental predictors of antibody response to vaccination in young Gambian adults.
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DOI：
10.1016/j.vaccine.2012.05.009
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发表时间：
2012-07-06
期刊：
影响因子：
5.5
通讯作者：
Prentice, Andrew M.
中科院分区：
文献类型：
--
作者：
Moore, Sophie E.;Richards, Anna A.;Goldblatt, David;Ashton, Lindsey;Szu, Shousun Chen;Prentice, Andrew M.
我们调查了冈比亚年轻成年人对疫苗接种反应的预测因素。我们专注于生命早期和当代的营养和环境暴露。疫苗接种前抗体滴度是疫苗接种反应的一致预测因素。没有观察到其他一致的关联。最近的研究将生命早期的营养暴露与儿童期后持续存在的功能性免疫的改变联系起来。在这里，我们调查预测抗体反应多糖疫苗在冈比亚成年人队列从出生到婴儿早期的详细记录。320名成年人接受了单剂量的伤寒沙门氏菌Vi多糖疫苗和23价荚膜多糖肺炎球菌疫苗。在基线和接种后14天采集的血清样本中测量抗Vi抗体水平和4种肺炎球菌血清型（1、5、14和23 F）的抗体，并与出生和婴儿早期的数据进行比较。接种后血清型14肺炎球菌疫苗的抗体滴度与出生至3个月龄的生长速度、12个月龄的婴儿体重和出生季节呈负相关，但未观察到与早期暴露的其他相关性。抗体水平的最强预测因子是接种前抗体滴度，成人身高和接种时的血清新蝶呤水平也有牵连。目前的研究并不支持这样的假设，即生命早期的营养暴露始终会损害对年轻成年人接种多糖疫苗的抗体反应。
► We investigate predictors of response to vaccination in young Gambian adults. ► We focus on both early-life and contemporary nutritional and environmental exposures. ► Pre-vaccination antibody titres were a consistent predictor of response to vaccination. ► No other consistent associations were observed. Recent research links nutritional exposures early in life with alterations in functional immunity that persist beyond childhood. Here we investigate predictors of antibody response to polysaccharide vaccines in a cohort of Gambian adults with detailed records from birth and early infancy available. 320 adults were given a single dose of a Vi polysaccharide vaccine for Salmonella typhi and a 23-valent capsular polysaccharide pneumococcal vaccine. Anti-Vi antibody levels and antibodies against 4 pneumococcal serotypes (1, 5, 14 and 23F) were measured in serum samples collected at baseline and then 14 days following vaccination and compared to data available from birth and early infancy. Post-vaccination antibody titres to serotype 14 of the pneumococcal vaccine were negatively associated with rate of growth from birth to three months of age, infant weight at 12 months of age and season of birth, but no other associations were observed with early-life exposures. The strongest predictor of antibody levels was pre-vaccination antibody titres, with adult height and serum neopterin levels at time of vaccination also implicated. The current study does not support the hypothesis that nutritional exposures early in life consistently compromise antibody response to polysaccharide vaccines administered in young adulthood.
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影响因子：
7.1
作者：
Moore, SE;Jalil, F;Hanson, LÅ
通讯作者：
Hanson, LÅ
影响因子：
5.2
作者：
Moore, SE;Morgan, G;Prentice, AM
通讯作者：
Prentice, AM
DOI：
10.1111/j.1651-2227.2009.01292.x
发表时间：
2009-07
期刊：
Acta paediatrica (Oslo, Norway : 1992)
影响因子：
--
作者：
Moore SE;Prentice AM;Wagatsuma Y;Fulford AJ;Collinson AC;Raqib R;Vahter M;Persson LA;Arifeen SE
通讯作者：
Arifeen SE
影响因子：
3.6
作者：
Abdullahi, Osman;Ayiro, Joyce;Scott, J. Anthony G.
通讯作者：
Scott, J. Anthony G.
影响因子：
2
作者：
HUSSEY, GD;KLEIN, M
通讯作者：
KLEIN, M