Age effects on tinnitus and hearing loss in CBA/CaJ mice following sound exposure.
Age effects on tinnitus and hearing loss in CBA/CaJ mice following sound exposure.
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DOI：
10.1186/2193-1801-3-542
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Galazyuk AV
中科院分区：
文献类型：
--
作者：
Longenecker RJ;Chonko KT;Maricich SM;Galazyuk AV
耳鸣是人类和实验动物在听觉损伤后发生的一种适应不良的神经性疾病。在我们之前的研究中，我们证明了声音暴露会导致耳鸣的行为证据在暴露的小鼠样本中发展。然而，这种耳鸣小鼠模型并没有考虑到长期的不适应可塑性或衰老，这些因素通常与人类耳鸣人群有关。因此，对同一组小鼠在暴露后360天内进行耳鸣监测。通过测量间隙诱导的声惊（GPIAS）预脉冲抑制来评估耳鸣的行为。对对照组（未暴露）和实验小鼠进行耳蜗组织学检查，以确定声音暴露是否引起明显的耳蜗损伤。我们发现，暴露后360天，绝大多数暴露小鼠表现出与暴露后84天相似的间隙检测缺陷。与对照样品相比，这些小鼠没有表现出明显的内/外毛细胞或螺旋神经节神经元的损失。最后，我们证明在暴露的动物中观察到的GPIAS缺陷不太可能完全由耳蜗损伤引起，而可能是中央听觉适应性不良可塑性的结果。综上所述，CBA/CaJ小鼠可以被认为是一种很好的动物模型，用于研究年龄对听损伤后耳鸣发展的影响。
Tinnitus is a maladaptive neuropathic condition that develops in humans and laboratory animals following auditory insult. In our previous study we demonstrated that sound exposure leads to development of behavioral evidence of tinnitus in a sample of exposed mice. However, this tinnitus mouse model did not account for long-term maladaptive plasticity or aging, factors that are commonly linked to the human tinnitus population. Therefore the same group of mice was monitored for tinnitus for 360 days post exposure. Tinnitus was assessed behaviorally by measuring gap-induced pre-pulse suppression of the acoustic startle (GPIAS). Cochlear histology was performed on both control (unexposed) and experimental mice to determine whether sound exposure caused any evident cochlear damage. We found that 360 days after exposure the vast majority of exposed mice exhibited similar gap detection deficits as detected at 84 days post exposure. These mice did not demonstrate significant loss of inner/outer hair cells or spiral ganglion neurons compared to the control sample. Lastly, we demonstrated that GPIAS deficits observed in exposed animals were unlikely exclusively caused by cochlear damage, but could be a result of central auditory maladaptive plasticity. We conclude that CBA/CaJ mice can be considered a good animal model to study the possible contribution of age effects on tinnitus development following auditory insult.
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影响因子：
5.3
作者：
Kujawa, SG;Liberman, MC
通讯作者：
Liberman, MC
DOI：
10.1007/s101620010030
发表时间：
2001-03-01
影响因子：
2.4
作者：
Bauer, CA;Brozoski, TJ
通讯作者：
Brozoski, TJ
DOI：
10.1111/ejn.12580
发表时间：
2014-07
期刊：
The European journal of neuroscience
影响因子：
--
作者：
Coomber B;Berger JI;Kowalkowski VL;Shackleton TM;Palmer AR;Wallace MN
通讯作者：
Wallace MN
影响因子：
2.8
作者：
Idrizbegovic, E;Canlon, B;Bogdanovic, N
通讯作者：
Bogdanovic, N
DOI：
10.1523/jneurosci.2845-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Kujawa SG;Liberman MC
通讯作者：
Liberman MC