The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective.
The Role of Innate Immune Cells in Cardiac Injury and Repair: A Metabolic Perspective.
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DOI：
10.1007/s11886-023-01897-4
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发表时间：
2023-07
影响因子：
3.7
通讯作者：
Cai, Shanshan
中科院分区：
文献类型：
--
作者：
Banerjee, Durba;Tian, Rong;Cai, Shanshan
最近的技术进步已经确定了心脏先天免疫细胞的不同亚群和作用，特别是巨噬细胞和中性粒细胞。巨噬细胞和中性粒细胞在心肌损伤中不同代谢途径的研究正在扩大。在这里，我们阐述了心脏巨噬细胞和中性粒细胞在伴随着他们的代谢在正常和患病的心脏的作用。单细胞技术结合命运定位已经确定了静息和患病心脏中存在的先天免疫细胞亚群簇。我们开始了解心脏驻留巨噬细胞的存在及其功能。驻留的巨噬细胞执行心脏稳态作用，而浸润的中性粒细胞和巨噬细胞在心脏损伤期间促进组织损伤，并最终在修复中发挥作用。先前的研究表明，在心脏损伤过程中，代谢途径调节巨噬细胞和中性粒细胞的表型。分析先天性免疫细胞的代谢，特别是慢性和急性心脏疾病期间驻留的巨噬细胞，可以进一步了解心脏免疫代谢。
Recent technological advances have identified distinct subpopulations and roles of the cardiac innate immune cells, specifically macrophages and neutrophils. Studies on distinct metabolic pathways of macrophage and neutrophil in cardiac injury are expanding. Here, we elaborate on the roles of cardiac macrophages and neutrophils in concomitance with their metabolism in normal and diseased hearts. Single-cell techniques combined with fate mapping have identified the clusters of innate immune cell subpopulations present in the resting and diseased hearts. We are beginning to know about the presence of cardiac resident macrophages and their functions. Resident macrophages perform cardiac homeostatic roles, whereas infiltrating neutrophils and macrophages contribute to tissue damage during cardiac injury with eventual role in repair. Prior studies show that metabolic pathways regulate the phenotypes of the macrophages and neutrophils during cardiac injury. Profiling the metabolism of the innate immune cells, especially of resident macrophages during chronic and acute cardiac diseases, can further the understanding of cardiac immunometabolism.
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DOI：
10.3390/antiox11081488
发表时间：
2022-07-29
期刊：
Antioxidants (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
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人骨髓中嗜中性粒细胞多形核白细胞的发展。
影响因子：
15.3
作者：
Bainton, D F;Ullyot, J L;Farquhar, M G
通讯作者：
Farquhar, M G
影响因子：
7.3
作者：
Fine N;Tasevski N;McCulloch CA;Tenenbaum HC;Glogauer M
通讯作者：
Glogauer M
影响因子：
2.9
作者：
Cottam, DR;Schaefer, PA;Angus, LDG
通讯作者：
Angus, LDG
影响因子：
37.8
作者：
Christ, Anette;Temmerman, Lieve;Biessen, Erik A. L.
通讯作者：
Biessen, Erik A. L.