T1-Weighted/T2-Weighted Ratio Mapping at 5 Months Captures Individual Differences in Behavioral Development and Differentiates Infants at Familial Risk for Autism from Controls.
T1-Weighted/T2-Weighted Ratio Mapping at 5 Months Captures Individual Differences in Behavioral Development and Differentiates Infants at Familial Risk for Autism from Controls.
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T1加权/T2加权比率映射在5个月捕捉行为发展的个体差异，并区分婴儿的自闭症家族风险从控制。
DOI：
10.1093/cercor/bhab069
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发表时间：
2021-07-29
期刊：
影响因子：
--
通讯作者：
Falck-Ytter T
中科院分区：
文献类型：
--
作者：
Darki F;Nyström P;McAlonan G;Bölte S;Falck-Ytter T
识别捕捉早期大脑发育并对个体行为差异敏感的结构措施是发育神经科学的优先事项，对我们理解典型和非典型人群具有潜在的意义。t1加权/ t2加权（T1w/T2w）比例映射，以前与髓鞘形成有关，在这方面代表了一个有趣的候选测量，作为标准磁共振成像（MRI）序列的可访问测量。然而，它作为早期婴儿测量的价值在很大程度上仍未被探索。在这里，我们比较了5个月大的自闭症谱系障碍（ASD）有家族风险的婴儿（n = 27）和没有自闭症风险升高的婴儿（n = 16）的T1w/T2w比率。我们发现，在广泛分布的白质和灰质区域中，ASD高风险婴儿的T1w/T2w比较低。在不同组间的区域，较高的T1w/T2w比值与较高的扫描年龄（范围：~ 4-6.5个月）密切相关，这意味着在短发育时间尺度上对成熟敏感。此外，这些地区较高的T1w/T2w比值与较高的并发发展水平测量得分相关。这些发现表明，T1w/T2w比率是一种发育敏感指标，应该在未来的典型和非典型婴儿群体研究中进一步探索。
Identifying structural measures that capture early brain development and are sensitive to individual differences in behavior is a priority in developmental neuroscience, with potential implications for our understanding of both typical and atypical populations. T1-weighted/T2-weighted (T1w/T2w) ratio mapping, which previously has been linked to myelination, represents an interesting candidate measure in this respect, as an accessible measure from standard magnetic resonance imaging (MRI) sequences. Yet, its value as an early infancy measure remains largely unexplored. Here, we compared T1w/T2w ratio in 5-month-old infants at familial risk (n = 27) for autism spectrum disorder (ASD) to those without elevated autism risk (n = 16). We found lower T1w/T2w ratio in infants at high risk for ASD within widely distributed regions, spanning both white and gray matter. In regions differing between groups, higher T1w/T2w ratio was robustly associated with higher age at scan (range: ~ 4–6.5 months), implying sensitivity to maturation at short developmental timescales. Further, higher T1w/T2w ratio within these regions was associated with higher scores on measures of concurrent developmental level. These findings suggest that T1w/T2w ratio is a developmentally sensitive measure that should be explored further in future studies of both typical and atypical infant populations.
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DOI：
10.1016/j.nicl.2017.09.026
发表时间：
2018
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bouziane C;Caan MWA;Tamminga HGH;Schrantee A;Bottelier MA;de Ruiter MB;Kooij SJJ;Reneman L
通讯作者：
Reneman L
影响因子：
4.7
作者：
Duerden, Emma G.;Mak-Fan, Kathleen M.;Roberts, S. Wendy
通讯作者：
Roberts, S. Wendy
DOI：
10.1523/jneurosci.2180-11.2011
发表时间：
2011-08-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Glasser MF;Van Essen DC
通讯作者：
Van Essen DC
影响因子：
4.6
作者：
Hagiwara A;Hori M;Kamagata K;Warntjes M;Matsuyoshi D;Nakazawa M;Ueda R;Andica C;Koshino S;Maekawa T;Irie R;Takamura T;Kumamaru KK;Abe O;Aoki S
通讯作者：
Aoki S
影响因子：
7.6
作者：
Falck-Ytter, Terje;Nystrom, Par;Bolte, Sven
通讯作者：
Bolte, Sven