Association of arsenic and metals with concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D among adolescents in Torreón, Mexico.
Association of arsenic and metals with concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D among adolescents in Torreón, Mexico.
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DOI：
10.1289/ehp.1307861
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发表时间：
2014-11
影响因子：
10.4
通讯作者：
Silbergeld EK
中科院分区：
文献类型：
--
作者：
Zamoiski RD;Guallar E;García-Vargas GG;Rothenberg SJ;Resnick C;Andrade MR;Steuerwald AJ;Parsons PJ;Weaver VM;Navas-Acien A;Silbergeld EK
背景：有限的数据表明，铅(铅)、镉(Cd)和铀(U)可能会扰乱维生素D的代谢，并抑制肾脏中维生素D活性代谢物1，25-二羟基维生素D[1，25(OH)2D]的生成。目的：探讨血铅(BPB)与尿砷(As)、镉(Cd)、钼(Mo)、铊(Tl)、铀(U)与维生素D代谢标志物[25(OH)D和1，25(OH)2D]的相关性。方法：我们对托雷翁的512名青少年进行了横断面研究，托雷翁是墨西哥的一个小镇，在居民区附近有一个铅冶炼厂。用原子吸收光谱法测定血铅。采用电感耦合等离子体质谱检测尿As、Cd、Mo、Tl、U。血清25(OH)D和1，25(OH)2D分别用化学发光法和放射免疫法测定。以维生素D标志物为结果的多变量线性模型被用来估计BPB、肌酐校正的尿砷和金属浓度与血清维生素D浓度的相关性，并控制了年龄、性别、肥胖、吸烟、社会经济状况和户外时间。结果：血25(OH)D水平与尿钼、尿TL呈正相关[分别高1.5(95%CI：0.4，2.6)和1.2(95%CI：0.3，2.1)ng/m L，暴露剂量加倍]。血清1，25(OH)2D与尿As和U呈正相关[分别高3.4(95%CI：0.9，5.9)和2.2(95%CI：0.7，3.7)pg/m L]，校正25(OH)D后相关性变化不大。结论：总体而言，我们的研究结果不支持砷或金属暴露对血清1，25(OH)2D浓度的负面影响。需要进一步的研究来证实血清1，25(OH)2D与尿铀和砷浓度之间的正相关性，并阐明潜在的潜在机制。引文：Zamoiski Rd，Guallar E，García-Vargas GG，Rothenberg SJ，Resnick C，Rubio Andrade M，Steuerwald AJ，Parsons PJ，Weaver VM，Navas-Acien A，Silbergeld EK。2014年。墨西哥托雷翁青少年中砷和金属与25-羟基维生素D和1，25-二羟基维生素D浓度的关系。环境健康展望122：1233-1238；http://dx.doi.org/10.1289/ehp.1307861
Background: Limited data suggest that lead (Pb), cadmium (Cd), and uranium (U) may disrupt vitamin D metabolism and inhibit production of 1,25-dihydroxyvitamin D [1,25(OH)2D], the active vitamin D metabolite, from 25-hydroxyvitamin D [25(OH)D] in the kidney. Objectives: We evaluated the association between blood lead (BPb) and urine arsenic (As), Cd, molybdenum (Mo), thallium (Tl), and U with markers of vitamin D metabolism [25(OH)D and 1,25(OH)2D]. Methods: We conducted a cross-sectional study of 512 adolescents in Torreón, a town in Mexico with a Pb smelter near residential areas. BPb was measured using atomic absorption spectrometry. Urine As, Cd, Mo, Tl, and U were measured using inductively coupled plasma mass spectrometry. Serum 25(OH)D and 1,25(OH)2D were measured using a chemiluminescent immunoassay and a radioimmunoassay, respectively. Multivariable linear models with vitamin D markers as the outcome were used to estimate associations of BPb and creatinine-corrected urine As and metal concentrations with serum vitamin D concentrations, controlling for age, sex, adiposity, smoking, socioeconomic status, and time outdoors. Results: Serum 25(OH)D was positively associated with urine Mo and Tl [1.5 (95% CI: 0.4, 2.6) and 1.2 (95% CI: 0.3, 2.1) ng/mL higher with a doubling of exposure, respectively]. Serum 1,25(OH)2D was positively associated with urine As and U [3.4 (95% CI: 0.9, 5.9) and 2.2 (95% CI: 0.7, 3.7) pg/mL higher, respectively], with little change in associations after additional adjustment for serum 25(OH)D. Pb and Cd were not associated with 25(OH)D or 1,25(OH)2D concentrations. Conclusions: Overall, our findings did not support a negative effect of As or metal exposures on serum 1,25(OH)2D concentrations. Additional research is needed to confirm positive associations between serum 1,25(OH)2D and urine U and As concentrations and to clarify potential underlying mechanisms. Citation: Zamoiski RD, Guallar E, García-Vargas GG, Rothenberg SJ, Resnick C, Rubio Andrade M, Steuerwald AJ, Parsons PJ, Weaver VM, Navas-Acien A, Silbergeld EK. 2014. Association of arsenic and metals with concentrations of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D among adolescents in Torreón, Mexico. Environ Health Perspect 122:1233–1238; http://dx.doi.org/10.1289/ehp.1307861
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影响因子：
4.5
作者：
Ponsoby, AL;McMichael, A;van der Mei, I
通讯作者：
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影响因子：
3
作者：
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通讯作者：
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DOI：
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发表时间：
1987-01-01
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作者：
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作者：
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DOI：
10.1161/atvbaha.112.248039
发表时间：
2012-11-01
影响因子：
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作者：
Brondum-Jacobsen, Peter;Benn, Marianne;Nordestgaard, Borge G.
通讯作者：
Nordestgaard, Borge G.