First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study.
First Trimester Phthalate Exposure and Infant Birth Weight in the Infant Development and Environment Study.
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DOI：
10.3390/ijerph13100945
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发表时间：
2016-09-23
影响因子：
--
通讯作者：
Swan SH
中科院分区：
文献类型：
--
作者：
Sathyanarayana S;Barrett E;Nguyen R;Redmon B;Haaland W;Swan SH
邻苯二甲酸酯暴露在孕妇中很普遍，但它是否与胎儿生长和出生体重有关仍有待确定。我们在一项妊娠队列研究中检查了妊娠早期产前邻苯二甲酸酯暴露是否与出生体重相关。我们从四个中心招募了2010-2012年的妊娠早期女性，并分析了具有完整尿邻苯二甲酸酯和出生记录数据的母亲/婴儿对（N = 753）。我们进行了多元线性回归，以检查按性别分层的足月儿和早产儿（≤37周）的产前对数比重校正尿邻苯二甲酸酯暴露是否与出生体重相关。我们观察到单羧基-邻苯二甲酸异壬酯（MCOP）暴露与足月男性出生体重增加（0.13 kg）之间存在显著相关性（95% CI 0.03，0.23）。在早产儿中，我们观察到出生体重增加0.49 kg（95% CI 0.09，0.89），与雌性（N = 33）邻苯二甲酸二乙基己酯（DEHP）代谢物浓度总和的一个对数单位变化相关。总之，我们观察到产前邻苯二甲酸酯暴露与出生体重之间的关联很少。正相关可能归因于足月儿中未解决的混杂因素和早产儿中有限的样本量。
Phthalate exposure is widespread among pregnant women but whether it is related to fetal growth and birth weight remains to be determined. We examined whether first trimester prenatal phthalate exposure was associated with birth weight in a pregnancy cohort study. We recruited first trimester pregnant women from 2010–2012 from four centers and analyzed mother/infant dyads who had complete urinary phthalate and birth record data (N = 753). We conducted multiple linear regression to examine if prenatal log specific gravity adjusted urinary phthalate exposure was related to birthweight in term and preterm (≤37 weeks) infants, stratified by sex. We observed a significant association between mono carboxy-isononyl phthalate (MCOP) exposure and increased birthweight in term males, 0.13 kg (95% CI 0.03, 0.23). In preterm infants, we observed a 0.49 kg (95% CI 0.09, 0.89) increase in birthweight in relation to a one log unit change in the sum of di-ethylhexyl phthalate (DEHP) metabolite concentrations in females (N = 33). In summary, we observed few associations between prenatal phthalate exposure and birthweight. Positive associations may be attributable to unresolved confounding in term infants and limited sample size in preterm infants.
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DOI：
10.1080/10934529.2015.1087753
发表时间：
2016-01-28
影响因子：
2.1
作者：
de Cock, Marijke;De Boer, Michiel R.;Van de Bor, Margot
通讯作者：
Van de Bor, Margot
影响因子：
3.6
作者：
Braun JM;Sathyanarayana S;Hauser R
通讯作者：
Hauser R
DOI：
10.1016/j.cppeds.2007.11.001
发表时间：
2008-02-01
影响因子：
1.6
作者：
Sathyanarayana, Sheela
通讯作者：
Sathyanarayana, Sheela
产前苯酚和邻苯二甲酸盐暴露和出生结果。
影响因子：
10.4
作者：
Wolff, Mary S.;Engel, Stephanie M.;Berkowitz, Gertrud S.;Ye, Xiaoyun;Silva, Manori J.;Zhu, Chenbo;Wetmur, James;Calafat, Antonia M.
通讯作者：
Calafat, Antonia M.
影响因子：
10.4
作者：
Casas M;Valvi D;Ballesteros-Gomez A;Gascon M;Fernández MF;Garcia-Esteban R;Iñiguez C;Martínez D;Murcia M;Monfort N;Luque N;Rubio S;Ventura R;Sunyer J;Vrijheid M
通讯作者：
Vrijheid M