A review of studies on animal reservoirs of the SARS coronavirus.
A review of studies on animal reservoirs of the SARS coronavirus.
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DOI：
10.1016/j.virusres.2007.03.012
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发表时间：
2008-04
期刊：
影响因子：
5
通讯作者：
Hu Z
中科院分区：
文献类型：
--
作者：
Shi Z;Hu Z
本文就SARS冠状病毒（SARS-CoV）动物宿主的研究进展作一综述。2003年，果子狸被怀疑是SARS爆发的源头，2004年被证实是症状轻微的SARS病例的直接来源。对果子狸体内SARS-CoV样病毒的序列分析表明，该病毒与人SARS-CoV的核苷酸同源性在99.6%以上，表明该病毒在果子狸群体中已经很长时间没有流行。将果子狸的10个病毒全基因组序列与人SARS冠状病毒的全基因组序列进行比对，发现果子狸病毒中存在26个保守的单核苷酸变异（SNV）。这些保守的SNV逐渐从2003年SARS流行的早期到晚期人类患者中分离的病毒基因组中丢失。2005年，马蹄蝙蝠被确定为一组冠状病毒的天然宿主，这些冠状病毒与SARS-CoV有远亲关系。蝙蝠SARS样冠状病毒基因组序列与SARS冠状病毒基因组序列的同源性为88-92%。阐明了蝙蝠SARS样冠状病毒在不同种类蝙蝠中的抗体和病毒RNA的流行情况以及蝙蝠SARS样冠状病毒的特征。除了果子狸和蝙蝠外，其他29种动物也进行了SARS冠状病毒检测，本文总结了结果。
In this review, we summarize the researches on animal reservoirs of the SARS coronavirus (SARS-CoV). Masked palm civets were suspected as the origin of the SARS outbreak in 2003 and was confirmed as the direct origin of SARS cases with mild symptom in 2004. Sequence analysis of the SARS-CoV-like virus in masked palm civets indicated that they were highly homologous to human SARS-CoV with nt identity over 99.6%, indicating the virus has not been circulating in the population of masked palm civets for a very long time. Alignment of 10 complete viral genome sequences from masked palm civets with those of human SARS-CoVs revealed 26 conserved single-nucleotide variations (SNVs) in the viruses from masked palm civets. These conserved SNVs were gradually lost from the genomes of viruses isolated from the early phase to late phase human patients of the 2003 SARS epidemic. In 2005, horseshoe bats were identified as the natural reservoir of a group of coronaviruses that are distantly related to SARS-CoV. The genome sequences of bat SARS-like coronavirus had about 88–92% nt identity with that of the SARS-CoV. The prevalence of antibodies and viral RNA in different bat species and the characteristics of the bat SARS-like coronavirus were elucidated. Apart from masked palm civets and bats, 29 other animal species had been tested for the SARS-CoV, and the results are summarized in this paper.
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影响因子：
11.4
作者：
Li, WH;Zhang, CS;Sui, JH;Kuhn, JH;Moore, MJ;Luo, SW;Wong, SK;Huang, IC;Xu, KM;Vasilieva, N;Murakami, A;He, YQ;Marasco, WA;Guan, Y;Choe, HY;Farzan, M
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56.9
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56.9
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3.8
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通讯作者：
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5.4
作者：
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通讯作者：
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