Reduced Central Retinal Artery Blood Flow Is Related to Impaired Central Visual Function in Retinitis Pigmentosa Patients.
Reduced Central Retinal Artery Blood Flow Is Related to Impaired Central Visual Function in Retinitis Pigmentosa Patients.
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减少的中央视网膜血流与色素性视网膜炎患者的中央视觉功能受损有关。
DOI：
10.1080/02713683.2017.1338350
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发表时间：
2017-11
影响因子：
2
通讯作者：
Bittner AK
中科院分区：
文献类型：
--
作者：
Kayser S;Vargas P;Mendelsohn D;Han J;Bi H;Benavente A;Bittner AK
我们评估了球后视网膜中央动脉（CRA）血流速度的重测重复性，并探讨了视网膜色素变性（RP）患者的视功能丧失程度是否与血流减少有关。我们在一个月内的两次访视中，使用彩色多普勒成像和频谱血流多普勒（GE Logiq 7 ultrasound）测量18例RP患者的CRA收缩期峰值流速（PSV）和舒张末期流速（EDV），以计算平均血流速度（MFV）。在这两次访视中的每次访视时，我们测量了ETDRS视力（VA）、快速对比敏感度功能（qCSF）、Goldmann视野（GVF）、10-2 Humphrey视野（HVF）和AdaptDx固定5°时的暗适应;在单次访视时获得多焦视网膜电图（mfERG）。访视内测量的PSV、EDV和MFV的平均变异系数为16.1-19.2%，访视间测量的平均变异系数为20.1-22.4%。在患者中，VA评估的视功能丧失更大（p = 0.04），熄灭与mfERG第1环的可测量振幅（p = 0.001），以及仅锥形假体与AdaptDx棒功能的对比（p = 0.002）与CRA的MFV降低具有统计学显著相关性，当包括多水平多变量回归模型沿着qCSF和HVF结果时，这些因素共同解释了MFV总方差的47%。GVF log视网膜面积（V4 e和III 4 e;分别为p = 0.30和p = 0.95）和GVF测试期间可测量的远周边视力（p = 0.66）与MFV无显著相关性。由于视杆细胞和视锥细胞功能丧失，CRA中的MFV随着中心视力受损而降低，具有良好的重测重复性，并且可以作为生物标志物结果，以确定对视网膜血流有间接影响的治疗的RP临床试验中改善的潜在生理基础。
We evaluated the test-retest repeatability of blood flow velocities in the retrobulbar central retinal artery (CRA) and explored whether reduced blood flow is related to the degree of visual function loss in retinitis pigmentosa (RP) patients with wide range of disease severity. We measured CRA peak systolic velocity (PSV) and end diastolic velocity (EDV) to calculate mean flow velocity (MFV) in 18 RP patients using color Doppler imaging with spectral flow Doppler (GE Logiq7 ultrasound) twice in each eye at each of two visits within a month. At each of these two visits, we measured ETDRS visual acuity (VA), quick Contrast Sensitivity Function (qCSF), Goldmann visual fields (GVF), 10–2 Humphrey visual fields (HVF), and dark-adaptation at 5° from fixation with the AdaptDx; multifocal electroretinography (mfERG) was obtained at a single visit. Mean coefficients of variation for PSV, EDV and MFV were 16.1–19.2% for within-visit measurements and 20.1–22.4% for between-visit measures. Across patients, greater visual function loss assessed with VA (p = 0.04), extinguished versus measurable amplitude in ring 1 for mfERG (p = 0.001), and cone-only versus rod function with the AdaptDx (p = 0.002) were statistically significantly correlated with reduced MFV in the CRA when included a multilevel multivariate regression model along with the qCSF and HVF results, which all together accounted for 47% of the total variance in MFV. GVF log retinal areas (V4e and III4e; p = 0.30 and p = 0.95, respectively) and measurable far peripheral vision during GVF testing (p = 0.66) were not significantly related to MFV. MFV in the CRA decreased with impaired central vision due to loss of both rod and cone function, had good test-retest repeatability, and may serve as a biomarker outcome to determine the potential physiological basis for improvements in RP clinical trials of therapies with indirect effects on blood flow to the retina.
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视网膜炎与视网膜炎色素性的眼睛中的视网膜血管衰减与视觉功能的关联。
DOI：
10.2147/opth.s66326
发表时间：
2014
期刊：
Clinical ophthalmology (Auckland, N.Z.)
影响因子：
--
作者：
Nakagawa S;Oishi A;Ogino K;Makiyama Y;Kurimoto M;Yoshimura N
通讯作者：
Yoshimura N
DOI：
10.1007/s00417-009-1178-3
发表时间：
2009-11-01
影响因子：
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作者：
Stalmans, Ingeborg;Siesky, Brent;Harris, Alon
通讯作者：
Harris, Alon
影响因子：
3.4
作者：
Pinto, Luis Abegao;Vandewalle, Evelien;Stalmans, Ingeborg
通讯作者：
Stalmans, Ingeborg
影响因子：
3.4
作者：
Murakami, Yusuke;Ikeda, Yasuhiro;Ishibashi, Tatsuro
通讯作者：
Ishibashi, Tatsuro
DOI：
10.1007/s00417-011-1757-y
发表时间：
2011-12-01
影响因子：
2.7
作者：
Beutelspacher, Sven C.;Serbecic, Nermin;Jonas, Jost B.
通讯作者：
Jonas, Jost B.