Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.

Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes.
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DOI:
10.1084/jem.140.5.1273
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发表时间:
1974-11-01
期刊:
The Journal of experimental medicine
影响因子:
--
通讯作者:
Shreffler DC
Shreffler DC
中科院分区:
其他
文献类型:
--
作者:
Frelinger JA;Neiderhuber JE;David CS;Shreffler DC

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我们已经证明在抗ia血清中存在与T细胞反应的特异性抗体,以及与B细胞,使用高度敏感的染料排除试验。这种抗血清与脾脏和淋巴结反应,呈典型的双相滴定曲线,可杀死高达70%的这些细胞。它还与抗可的松胸腺细胞发生反应。A.TH -α-。TL血清可被脾脏、淋巴结、抗可的松胸腺或正常胸腺细胞吸收。进一步在BALB/c裸体体内吸收不能去除对正常BALB淋巴结淋巴细胞的所有细胞毒活性,而完全去除对裸细胞的活性。来源于C57Br白血病的Thy-1阳性细胞系对这种抗ia血清有反应。
We have demonstrated in an anti-Ia serum the presence of specific antibodies reacting with T cells, as well as with B cells, using a highly sensitive dye exclusion test. This antiserum reacts with both spleen and lymph node in a characteristic biphasic titration curve killing up to 70% of these cells. It also reacts with cortisone-resistant thymocytes. The A.TH-α-A.TL serum can be absorbed with spleen, lymph node, cortisone-resistant thymus, or normal thymus cells. Further in vivo absorptions in BALB/c nude cannot remove all of the cytotoxic activity for normal BALB lymph node lymphocytes, while completely removing the activity for nude cells. A Thy-1 positive cell line derived from a C57Br leukemia is reactive with this anti-Ia serum.
DOI: 10.1084/jem.136.6.1430
发表时间: 1972-12-01
影响因子: 15.3
作者:
Bach, F H;Widmer, M B;Bach, M L;Klein, J
通讯作者: Klein, J
DOI: 10.1084/jem.137.5.1213
发表时间: 1973-05-01
期刊: The Journal of experimental medicine
影响因子: --
作者:
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通讯作者: Park JM
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发表时间: 1973-11-01
期刊: The Journal of experimental medicine
影响因子: --
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通讯作者: Kindred B
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发表时间: 1973-01-01
影响因子: 11.1
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