Cognitive Function and Serum Hormone Levels Are Associated with Gray Matter Volume Decline in Female Patients with Prolactinomas.
Cognitive Function and Serum Hormone Levels Are Associated with Gray Matter Volume Decline in Female Patients with Prolactinomas.
复制标题
认知功能和血清激素水平与女性泌乳素瘤患者的灰质体积下降有关。
DOI：
10.3389/fneur.2017.00742
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发表时间：
2017
影响因子：
3.4
通讯作者：
Xu G
中科院分区：
文献类型：
--
作者：
Yao S;Song J;Gao J;Lin P;Yang M;Zahid KR;Yan Y;Cao C;Ma P;Zhang H;Li Z;Huang C;Ding H;Xu G
高催乳素血症患者有认知障碍的报道;然而，对催乳素瘤患者与高催乳素血症相关的脑结构改变缺乏了解。因此，我们的目的是确定泌乳素瘤脑结构的变化，并确定这些变化是否与认知能力和临床特征有关。参与者为32名女性泌乳素瘤患者和26名年龄、性别、教育和利手相匹配的健康对照（HC）。所有参与者都接受了磁共振成像脑部扫描，神经心理学评估和临床评估。基于体素的形态学分析用于识别灰质体积（GMV）的变化。偏相关分析和多元线性回归分析，以确定GMV，认知和临床特征之间的关系。与HC相比，泌乳素瘤患者的左侧海马、左侧眶额皮质、右侧中额皮质（MFC）和右侧下额皮质（IFC）的GMV降低。此外，患者在言语记忆和执行功能测试中的表现比对照组差，这分别与左侧海马和右侧MFC的GMV显著相关。此外，在患者中，我们发现血清催乳素水平与左侧海马和右侧IFC的GMV呈负相关，而左侧海马的GMV与血清雌二醇和黄体生成素水平呈正相关。在泌乳素瘤患者中，已经确定了特定的脑结构异常，并与认知障碍和激素功能障碍有关。这项研究增强了我们对泌乳素瘤可能发生的脑结构变化的理解，并为以前与高泌乳素血症相关的行为发现提供了新的和基本的证据。
Cognitive impairments have been reported in patients with hyperprolactinemia; however, there is a lack of knowledge of brain structure alterations relevant to hyperprolactinemia in prolactinomas. Thus, we aimed to identify changes in brain structure in prolactinomas and to determine whether these changes are related to cognitive performance and clinical characteristics. Participants were 32 female patients with prolactinomas and 26 healthy controls (HC) matched for age, sex, education, and handedness. All participants underwent magnetic resonance imaging brain scans, neuropsychological assessments, and clinical evaluations. Voxel-based morphometry analysis was used to identify changes in gray matter volume (GMV). Partial correlation analysis and multiple linear regression were performed to determine the relationship between GMV, cognition, and clinical characteristics. Compared to HC, patients with prolactinomas demonstrated a decrease in GMV in the left hippocampus, left orbitofrontal cortex, right middle frontal cortex (MFC), and right inferior frontal cortex (IFC). In addition, patients performed worse than controls on tests for verbal memory and executive function, and this was significantly related to the GMV of the left hippocampus and right MFC, respectively. Moreover, in the patients, we found a negative relationship between serum prolactin levels and the GMV of the left hippocampus and right IFC, whereas a positive relationship was found between the GMV of the left hippocampus and serum levels of estradiol and luteinizing hormone. In patients with prolactinomas, specific brain structure abnormalities have been identified and are associated with cognitive impairments and dysfunctional hormones. This study enhances our understanding of brain structure changes that may occur with prolactinomas and provides novel and fundamental evidence for previous behavioral findings relevant to hyperprolactinemia.
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DOI：
10.1177/1073858413519865
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bean LA;Ianov L;Foster TC
通讯作者：
Foster TC
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10.1177/0269216307087148
发表时间：
2008-03-01
期刊：
Journal of psychopharmacology (Oxford, England)
影响因子：
--
作者：
Fitzgerald, Peter;Dinan, Timothy G
通讯作者：
Dinan, Timothy G
影响因子：
2.4
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Demakis, GJ
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影响因子：
3.2
作者：
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Sun, Qing-Fang