Education differentially contributes to cognitive reserve across racial/ethnic groups.
Education differentially contributes to cognitive reserve across racial/ethnic groups.
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DOI：
10.1002/alz.12176
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Manly JJ
中科院分区：
文献类型：
--
作者：
Avila JF;Rentería MA;Jones RN;Vonk JMJ;Turney I;Sol K;Seblova D;Arias F;Hill-Jarrett T;Levy SA;Meyer O;Racine AM;Tom SE;Melrose RJ;Deters K;Medina LD;Carrión CI;Díaz-Santos M;Byrd DR;Chesebro A;Colon J;Igwe KC;Maas B;Brickman AM;Schupf N;Mayeux R;Manly JJ
我们研究了不同种族/民族的教育程度是否对认知储备（CR）有不同的贡献。共有1553名非西班牙裔白人（白人）、非西班牙裔黑人（黑人）和西班牙裔在华盛顿高地-因伍德哥伦比亚老龄化项目（WHICAP）完成了结构磁共振成像。混合生长曲线模型用于检查大脑完整性指标（海马体积、皮质厚度和白色高信号[WMH]体积）对记忆和语言轨迹的影响是否因种族/民族群体的教育而改变。较高的教育程度减弱了WMH负担对记忆（β =-0.03; 99% CI：-0.071，-0.002）和语言能力下降（β =-0.024; 99% CI：-0.044，-0.004）的负面影响，以及皮质变薄对白人语言能力水平的影响，但对黑人或西班牙裔没有影响。受教育程度在不同种族/族裔群体中对CR的贡献并不相似。
We examined whether educational attainment differentially contributes to cognitive reserve (CR) across race/ethnicity. A total of 1553 non-Hispanic Whites (Whites), non-Hispanic Blacks (Blacks), and Hispanics in the Washington Heights-Inwood Columbia Aging Project (WHICAP) completed structural magnetic resonance imaging. Mixture growth curve modeling was used to examine whether the effect of brain integrity indicators (hippocampal volume, cortical thickness, and white matter hyperintensity [WMH] volumes) on memory and language trajectories was modified by education across racial/ethnic groups. Higher educational attainment attenuated the negative impact of WMH burden on memory (β = −0.03; 99% CI: −0.071, −0.002) and language decline (β = −0.024; 99% CI:− 0.044, −0.004), as well as the impact of cortical thinning on level of language performance for Whites, but not for Blacks or Hispanics. Educational attainment does not contribute to CR similarly across racial/ethnic groups.
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影响因子：
3.7
作者：
Dickerson, Bradford C.;Bakkour, Akram;Salat, David H.;Feczko, Eric;Pacheco, Jenni;Greve, Douglas N.;Grodstein, Fran;Wright, Christopher I.;Blacker, Deborah;Rosas, H. Diana;Sperling, Reisa A.;Atri, Alireza;Growdon, John H.;Hyman, Bradley T.;Morris, John C.;Fischl, Bruce;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1017/s1355617710001748
发表时间：
2011-07
影响因子：
2.6
作者：
Jones, Richard N.;Manly, Jennifer;Glymour, M. Maria;Rentz, Dorene M.;Jefferson, Angela L.;Stern, Yaakov
通讯作者：
Stern, Yaakov
影响因子：
5.6
作者：
Pettigrew C;Soldan A
通讯作者：
Soldan A
影响因子：
3.7
作者：
Mungas, Dan;Reed, Bruce R.;DeCarli, Charles
通讯作者：
DeCarli, Charles
DOI：
10.1017/s1355617702813157
发表时间：
2002-03-01
影响因子：
2.6
作者：
Manly, JJ;Jacobs, DM;Stern, Y
通讯作者：
Stern, Y